| Project/Area Number |
10670379
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Osaka Prefectural Institute of Public Health |
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Principal Investigator |
NAKAMURA Sei-ichi Osaka Prefectural Institute of Public Health, Dept. Industrial Health, Senior researcher, 労働衛生部, 主任研究員 (80167551)
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| Co-Investigator(Kenkyū-buntansha) |
KOSAKA Hirosi Osaka Prefectural Institute of Public Health, Dept. Industrial Health, Senior researcher, 労働衛生部, 主任研究員 (30250327)
AKASAKA Susumu Osaka Prefectural Institute of Public Health, Dept. Industrial Health, Senior researcher, 労働衛生部, 主任研究員 (10158719)
ODA Hajime Osaka Prefectural Institute of Public Health, Dept. Industrial Health, Vice-director, 部長兼副所長 (00132845)
ISHIKAWA Hideki Osaka Medical Center for Cancer and Caldiovascular Diseases, Dept. Cancer Epidemiology, Senior researcher, 研究所10部, 医長
SATO Shinichi Osaka Prefectural Institute of Public Health, Dept. General Affairs, Technical Official, 総務部, 技術吏員
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1999: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1998: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | colorectal cancer / high risk group / feces / dietary guidance / whert bran / mutagenicity / umu test / cancer prevention |
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| Research Abstract |
It is suggested that the development of the cancer is dependent of the environmental factors, especially, the dietary patterns. Therefore, we started the studies of preventive methods against cancer. The study included two examinations. One is the comparative study of the fecal mutagenicity between healthy group and high risk group for colorectal cancer, who have multiple colorectal tumors, aged between 40〜65 years old, have no history of intestinal resection except appendectomy, be presently free of malignant disease, and have no serious complications. Another is the study of the effect of the dietary guidances on the fecal mutagenicity of the high risk group. The high risk groups were divided to 4 groups as follows, 1)dietary guidance + biscuit containe whert bran, 2)dietary guidance + tablet of lactic bacteria, 3)dietary guidance + both of biscuit and tablet, 4)dietary guidance only.
For the comparative study, we observed fecal mutagenicity and obtained some results as follows: 1)18 of 383 samples showed mutagenicity in high risk group. 2)Fecal mutagenicity of the high risk group was tend to lower than that of the healthy group.
For the examination for the effects of dietary guidance, mutation assay for about 1200 fecal samples and follow-up observation was now continued.
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