Application of cyclopropane fatty acid in heart mitochondria to determine the time after death.
| Project/Area Number |
10670383
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IWASE Hirotaro University of Tokyo, Graduate School of Medicine, Lecturer, 大学院・医学系研究科, 講師 (30272420)
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| Co-Investigator(Kenkyū-buntansha) |
TAKATORI Takehiko National Research Institute of Police Science, Chief, 所長(研究職) (30001928)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1999: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1998: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | mitochondria / cyclopropane fatty acid / forensic medicine |
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| Research Abstract |
1) We found that when mitochondria of bovine heart was degraded by oxidants, some kinds of hydroxy, keto, and epoxy compounds of linoleic acid was formed.
2) We found C-17 cyclopropane fatty acid in the sn-2 position of phspholipids which constitute mitochondrial membrane, and it also existed in cell membranes and microsomes of human heart, liver and rat liver.
3) Free C-17 cyclopropane fatty acid was found in the sera of cadavers, whereas it was not found in those of healthy living persons.
4) No relationships between the times after death and cyclopropane fatty acid concentrations in human sera was found.
5) We found that C-17 cyclopropane fatty acid inhibited the contraction of cardiac papillary muscles.
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Report
(3 results)
Research Products
(15 results)
