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Application of cyclopropane fatty acid in heart mitochondria to determine the time after death.

Research Project

Project/Area Number 10670383
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Legal medicine
Research InstitutionThe University of Tokyo

Principal Investigator

IWASE Hirotaro  University of Tokyo, Graduate School of Medicine, Lecturer, 大学院・医学系研究科, 講師 (30272420)

Co-Investigator(Kenkyū-buntansha) TAKATORI Takehiko  National Research Institute of Police Science, Chief, 所長(研究職) (30001928)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1999: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1998: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordsmitochondria / cyclopropane fatty acid / forensic medicine
Research Abstract

1) We found that when mitochondria of bovine heart was degraded by oxidants, some kinds of hydroxy, keto, and epoxy compounds of linoleic acid was formed.
2) We found C-17 cyclopropane fatty acid in the sn-2 position of phspholipids which constitute mitochondrial membrane, and it also existed in cell membranes and microsomes of human heart, liver and rat liver.
3) Free C-17 cyclopropane fatty acid was found in the sera of cadavers, whereas it was not found in those of healthy living persons.
4) No relationships between the times after death and cyclopropane fatty acid concentrations in human sera was found.
5) We found that C-17 cyclopropane fatty acid inhibited the contraction of cardiac papillary muscles.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report

Research Products

(15 results)

All Other

All Publications (15 results)

  • [Publications] Iwase, H.: "Calcium ions potentiate lipoxygenase activity of cytochrome c at the physiological pH"Biochemical and Biophysical Research Communications. 243(2). 485-491 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Iwase, H.: "Formation of keto and hydroxy compounds of linoleic acid in submitochondrial particles of bovine heart..."Free Radical Biology and Medicine. 24(9). 1492-1503 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Iwase, H.: "Calcium is required for quasi-lipoxygenase activity of hemoproteins"Free Radical Biology and Medicine. 25(8). 943-952 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sakurada, K.: "Identification of cis-9,10-methylenehexadecenoic acid in submitochondrial particles of bovine heart"Biochimica et Biophysica Acta. 1437. 214-222 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ueyama, T.: "Emotional stress induces immediate-early gene expression in rat heart via activation of alpha- and beta-adrenoceptors"Am J Physiol.. 277. H1553-1561 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 原田一樹: "「虚血神経細胞死」(分担執筆)監修 金澤一郎等"サイメッドパブリケーションズ. 8 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Iwase, H.: "Calcium ions potentiate lipoxygenase activity of cytochrome c at the physiological pH."Biochem. Biophys. Res. Commun.. 243. 485-491 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Iwase, H.: "Formation of keto and hydroxy compounds of linoleic acid in submitochondrial particles of bovine heart."Free Rad. Biol. Med.. 24. 1492-1503 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Iwase, H.: "Calcium is required for quasilipoxygenase activity of hemoproteins"Free Rad. Biol. Med.. 25. 943-952 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sakurada, K.: "Identification of cis-9, 10-methylenehexadecenoic acid in submitochondrial particles of bovine heart."Biochim. Biophys. Acta. 1437. 214-222 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sakurada,K.: "Identification of cis-9,10-methylenehexadecenoic acid in submitochondrial particles of bovine heart"Biochimica et Biophysica Acta. 1437. 214-222 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hirotaro Iwase: "Calcium ions potentiate lipoxygenase activity of Cytochromec at the physiologicel pH." Biochemical and Biophysical Research Commanications. 243(2). 485-491 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hirotaro Iwase: "Formation of keto and hydroxy Compounals of lineleic actcl in Submitochendrial particles of bavine heart" Free Radical Biology and Medicine. 24(9). 1492-1503 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hirotaro Iwase: "Calcium is reguired for guesi-lipoxygerase activity of hemoproteing" Free Redical Biology and Medictne. 25(8). 943-952 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Koichi Sakurada: "Identification of cis-9,10-methylenehexadecenoic acil in submitochendrial particles of bavire heart" Biochimica et Biophysica Acta. (in press). (1999)

    • Related Report
      1998 Annual Research Report

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Published: 1998-03-31   Modified: 2016-04-21  

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