| Project/Area Number |
10670400
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Saitama Medical University |
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Principal Investigator |
HARA Masaaki Saitama Medical School, School of medicine, Research Assistant, 医学部, 助手 (50129160)
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| Co-Investigator(Kenkyū-buntansha) |
NEMOTO Ken Saitama Medical School, School of medicine, Assistant Professor, 医学部, 講師 (40267571)
TAKADA Aya Saitama Medical School, School of medicine, Research Assistant, 医学部, 助手 (30245196)
SAITO Kazuyuki Saitama Medical School, School of medicine, Professor, 医学部, 教授 (10215535)
SHINOZUKA Tatuo Keio University Assistant Professor, 医学部, 講師 (70095610)
KIDO Akia Yamanasi Medical University, Assistant Professor, 医学部, 助教授 (60021440)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2000: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1999: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1998: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | LDLR polymorphism / Causes of death / Aortic diseases / Ischemic heart diseases / LDL receptor / Japanese / 多型 / PCR / LDLR多型 / 心・血管疾患 / common mutation / 心・大動脈疾患 |
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| Research Abstract |
The association between LDLR polymorphism and some diseases was investigated on blood samples from 274 autopsy case. The frequency of LDLR AA type in natural death group was significantly higher than that in traumatic death group (P=0.0114). The differences between the frequency of LDLR A in cardiac and aortic disease group and that in head injury or vascular injury group were statistically significant (P<0.025). IN the group of aortic dissection and ischmic heart disease, the frequency of LDLR A was remarkably high. The genetic abnormalities of the LDL receptor may play some part in the etiology of cardiac and vascular disorders.
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