• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular cell-biological pathogenesis of insnlin autoimmune syndrome

Research Project

Project/Area Number 10670432
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 内科学一般
Research InstitutionTokyo Women's Medical University

Principal Investigator

UCHIGATA Yasuko  Tokyo Women's Med. Univ. Associate, 医学部, 助教授 (50193884)

Co-Investigator(Kenkyū-buntansha) IWAMOTO Yasuhiko  Tokyo Women's Med Univ Prof., 医学部, 教授 (60143434)
箱田 雅之  東京女子医科大学, 医学部, 講師 (70208429)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2000: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1998: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsInsulin Autoimmune Syndrome / Insulin autoantibody / clonality / DR4 allele / HnArestriction / クロナーリテイ / DRアリール / HLA / T細胞レセプター
Research Abstract

Insulin autoimmune syndrome (IAS) is a syndrome characterized by hypoglycemia, especially in fasting which was first reported by Hirata (JnJpn Diabetes SOC 13 : 312,1970). Insulinautoantibies has 2 clonalities which is polyclonal and monoclonal. Both of them have high-capacity and low-affinity binding constant which are determined by Scatchiard analysis using human insulin.
Since reported by Hirata in 1970, we collected 244 patient record with insulin autoimmune syndrome in Japan until 1997. A half of them was treated with sulfhydroxy compounds such as Thiola and Tathione. Approximately 9 people are supposed to develop IAS per year.
Insulin-reactive T cell receptors had a high frequent usage of Vβ6,8, and 20. Moreover, they were Th T lymphocytes.
There are very rare syndrome in Caucasians. However, there are some Caucasian patients with IAS.We diagnosed 2 Portuguese patient and 1 Argentina patient with IAS.One of Portuguese patients had polyclonal Insulin autoantiby with DRB1^*0406/^* 1302, and the other had monoclonal insulin autoantibdy wi DRB1^*0403/0701. The Argentina patient with IAS had monoclonal insulin autoantibody with DRB1^*0401/0403. The results suppots our hypothesis that polyclonal insulin antibody production in IAS is ristricted with DRB1^*0406 and monoclonal antibody production ia related with the DRB1 allele except DRB1^*0406.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Y.Uchigata,Y.Hirata: "Insulin autoimmune syndrome (IAS, Hirata disease)"Ann.Med.Interne. 150. 245-253 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Uchigata et al: "Worldwide differences in incidences of insulin autoimmune syndrome"Human Immunology. 61. 154-157 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Uchigata,Y.Hirata: "Endocrine and Organ Specific Autoimmunity Chap 7. Insulin Autoimmune Syndrome"R.G.Landes (TX.USA). 271 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Uchigata Y, Hirata Y, Omori Y, Iwamoto Y, Tokunaga K.: "Worldwide differences in incidence of insulin autoimmune syndrome (IAS, Hirata disease) with respect to the evolusion of HLA-DR4 alleles"Human Immunology. 61. 154-157 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Uchigata Y Hirata Y.: "Insulin autoimmune syndrome (IAS, Hirata disease)"Ann Med Interna. 150. 245-253 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Uchigata Y.Hirata Y.: "Insulin autoimmune syndrome (IAS, Hirata disease)"Endocrine and Organ Specific Autoimmunity (R.G.Landes, USA). 135-148 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Uchigata,Y.Hirata: "Insulin autoimmune syndrome (IAS, Hirata disease)"Ann.Med.Interne. 150. 245-253 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Y.Uchigata et al: "Worldwide differences in incidence of insulin autoimmune syndrome"Human Immunology. 61. 154-157 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Y.Uchigata,Y.Hirata: "Endocrine and Organ Specific Autoimmunity Chap 7.Insulin Autoimmune Syndrome"R.G.Landes (TX.USA). 271 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 154-157

    • Related Report
      1999 Annual Research Report

URL: 

Published: 1998-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi