| Project/Area Number |
10670460
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kanazawa University |
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Principal Investigator |
NAKABAYASHI Hajime Kanazawa University, Health Service Center, Professor, 保健管理センター, 教授 (20019988)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Atsushi Kanazawa Medical University, Internal Medicine, Assist. Professor, 内分泌内科, 講師 (70262574)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | Vagal Nerve / Stomach / Somatostatin / Neurochemoreception / 肝迷走神経機構 |
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| Research Abstract |
Recently we have found histologically the neural system associated with the fundic vein of the stomach, a somatostatin secreting organ, contains somatostatin receptor. To determine if the gastric vagus is receptive to gastric somatostatin release, the gastric vagal afferent activity was measured upon a subserosal injection of somatostatin at a local physiological concentration (100 〜 1000 pg/ml) in rats anesthetized with urethan and chloralose. The fundic, but not antral, somatostatin injection facilitated significantly the gastric afferents, and further led to significant suppression of the gastric efferents. The suppression of the dorsal (or ventral) efferents disappeared in the ventral (or dorsal) vagotomized rat. Furthermore, the facilitation of the afferents became far more prominent in hepatic vagotomized rats, accompanying the nonsuppressible efferents. The results indicate that somatostatin released from the fundic stomach is neurochemoreceptively monitored by the gastric vagus, resulting probably in uique enterogastrone effect mediated by the somatostatin-induced gastric vagovagal refex. The observation also suggests a link between the gastric monitoring system and the hepatic vagal innervation, leaving a large part of the neural pathways unknown.
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