| Project/Area Number |
10670489
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Miyazaki Medical College |
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Principal Investigator |
MATSUKURA Shigeru Miyazaki Medical College, Third Department of Internal Medicine, Professor, 医学部, 教授 (70030939)
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| Co-Investigator(Kenkyū-buntansha) |
KANGAWA Kenji National Cardiovascular center Research Institute, Department of Biochemistry, Director, 生化学部, 部長 (00112417)
NAKAZATO Masamitsu Miyazaki Medical College, Third Department of Internal Medicine, Associate Professor, 医学部, 講師 (10180267)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1999: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1998: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | uroguanylin / guanylin / cyclic GMP / guanylate cyclase / salt and water metabolism / cycilc GMP |
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| Research Abstract |
Uroguanylin, a new natriuretic peptide originally isolated from urine, stimulates the membrane guaynlate cyclase C receptor. No information, however, is available on the plasma and urine levels of uroguanlyin in nephrotic syndrome(NS), the state associated with sodium and water retention, using a sensitive redioimmunoassay, we measured the plasma and urine concentrations of immunoreactive (ir-) uroguanylin in NS patients and compared them with those of patients with non-nephrotic glomerulonephritis. Plasma ir-uroguanylin, blood pressure and the cardiothoracic ratio were higher, and urine excretion of ir-urognanylin was lower in the NS patients. Plasma ir-uroguanylin in the NS patients significantly decreased during remission as compared with findings on admission. There was significant inverse correlation between the concentration of plasma ir-uroguanylin and that of serum total protein or albumin. Moreover, fluid retention in the NS patients was correlated with the changes in plasma ir-uroguanylin between admission and remission, indicative that the plasma concentration increases with the severity of the nephrotic state. Taking into account its potent natriuretic effect, these findings suggest that uroguanylin may function in the pathophysiological mechanism in NS.
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