• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Assessment of Tissue Hypoxia Associated with Sleep-induced Respiratory Disturbances and New Classification of Disease Severity

Research Project

Project/Area Number 10670527
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

NISHIMURA Masharu  Hokkaido University, School of Medicine, Associate Professor, 医学部, 助教授 (00208224)

Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥3,300,000 (Direct Cost: ¥3,300,000)
Keywordssleep spnea / hypoxia / uric acid / adenosine / heart rate / arterial desaturation / 組織低酸素 / 心拍変動
Research Abstract

Although the overnight increase in urinary uric acid/ creatinine ratio (AUA/Cr) is considered by some to be a marker of arterial oxygen desaturation in obstructive sleep apnea syndrome (OSAS), this index does not necessarily parallel the level of arterial desaturation. We examined the validity of △UA/Cr as a marker of tissue hypoxia, not of arterial desaturation, during sleep by measuring the plasma level of adenosine, an intermediary in the process of ATP degradation to uric acid. Additionally, we hypothesized that inter-subject variability in the heart rate response to apnea is a determinant of tissue hypoxia. Methods and Results: We classified 18 patients with OSAS who had apnea-associated moderate to severe arterial desaturation into the two groups; the △UA/Cr-positive group who were considered to have tissue hypoxia and the △UA/Cr-normal group who were not. Venous levels of adenosine were measured before, during and after sleep. Although there were no significant differences between the two groups in either arterial desaturation parameters or apnea index, the plasma level of adenosine during sleep was significantly higher in the ΔUA/Cr-positive group than the normal group (15.2【minus-plus】1.9 SE nM vs. 9.8【minus-plus】1.7 nM, p <0.05]. Successful treatment with nasal CPAP significantly decreased both indices only in the ΔUA/Cr-positive group, but did not in the normal group. The magnitude of heart rate increase after the termination of apnea was significantly smaller in the △UA/Cr-positive group. Conclusions: The ΔUA/Cr can be a marker of tissue hypoxia, which may not be predicted by arterial desaturation indices in sleep apnea syndrome. The poor heart rate response to apnea is a determinant of tissue hypoxia.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Saito H. et al.: "Plasma concentration of adenosine during normoxia and moderate hypaxia in humans"Am.J.Respir.Crit.Care Med.. 159. 1014-1018 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Saito S. et al.: "Effects of inhaled bronchodilators on pulmonary hemodynamics at rest and during oxercise in patients with COPD"Chest. 115. 376-382 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Saito H.et al.: "Effect of hypoxia on airway responsireness to methacholine in subjects with airway hyperresponsiveness"Chest. 116. 1653-1658 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H Sarto, et al: "Plasma level of adenosine during normoxia and moderate hypoxia in humans."Am. J. respir. Cnt Care Med.. 159. 1014-1018 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S. Saito, et al: "Effects of inhaled bronchodilators on pulmonary hemodynamics at rest and during exercise in patients with COPD"Chest. 115. 376-382 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Saito, et al: "Effect of hypoxia on airway responsiveness to methacholine in subjects with airway hyperresponsiveness."Chest. 116. 1653-1658 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Saito, H., Nishimura, M., Shinano, H. et al.: "Plasma concentration of adenosine during normoxia and moderate hypoxia in humans"Am. J. Respir. Crit. Care Med.. 159. 1014-1018 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Saito, S., Miyamoto, K., Nishimura, M. et al.: "Effects of inhaled bronchodilators on pulmonary hemodynamics at rest and during exercise in patients with COPD"Chest. 115. 376-382 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Saito, H., Nishimura, M., Shinano, H. et al.: "Effect of hypoxia on airway responsiveness to methacholine in subjects with airway hyperresponsiveness"Chest. 116. 1653-1658 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hiroshi Saito, et al: "Plasma concentration of adenosine during normoxia and moderate hypoxia in humans" Am.J.Resp.Crit.Care Med.159(in press). (1999)

    • Related Report
      1998 Annual Research Report

URL: 

Published: 1998-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi