| Project/Area Number |
10670533
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAKIZAWA Hajime The Univ. Tokyo, Dpt. Med. Phys. Therapy, Lecturer, 医学部・附属病院, 講師 (80171578)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Makoto The Univ. Tokyo, Dpt. Med. Phys. Therapy, Assist Prof. of Med., 医学部・附属病院, 医員
ISHII Akira The Univ. Tokyo, Dpt. Med. Phys. Therapy, Assist Prof. of Med., 医学部・附属病院, 助手 (30272553)
SHOJI Shunsuke The Univ. Tokyo, Dpt. Med. Phys. Therapy, Assist Prof. of Med., 医学部・附属病院, 助手 (10171018)
KOHYAMA Tadashi The Univ. Tokyo, Dpt. Med. Phys. Therapy, Assist Prof. of Med., 医学部・附属病院, 医員
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1999: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1998: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | Allergic airway inflammation / Bronchial asthma / Chemokine gene expression / Airway epithelial cell / T cell / Chemotactic factor / Adhesion molecule / co-stimulatory molecule / アレルギー性気道炎症 / ケモカイン / RANTES / ICAM-1 |
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| Research Abstract |
Airway epithelial cells are known to play an integral role in the airway responses thorough the production of cytokines/chemokines important in the pathogenesis of bronchial asthma. We could demonstrated that : 1) human airway epithelial cells had potentials to express and release RANTES and TARC , both being chemotactic for T lymphocytes. 2) They expressed adhesion molecules and co-stimulatory molecules such as ICAM-1 (CD54). B7-1 CCD80) and B7-2 (CD86). When T lymphocytes were co-incubated with airway epithelial cells, they were stimulated to release IL-4 and IL-13, which are important Th2-type cytokines. Therefore, airway epithelial cells can regulate not only cell migration and attachment but also activation of T cells. 3) In murine models of allergic asthma, there was an intense expression of TARC in the airway epithelium by immunohistochemistry. Above observations strongly suggested that airway epithelial cells play an important role in the regulation of T lymphocyte functions in allergic airway inflammation found in asthma.
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