| Project/Area Number |
10670544
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tottori University |
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Principal Investigator |
BURIOKA Naoto Tottori University, Hospital, Assistant Prof., 医学部附属病院, 講師 (50252854)
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| Co-Investigator(Kenkyū-buntansha) |
TERAMO Hidemi Tottori University, Hospital, Assistant, 医学部附属病院, 助手 (80304236)
CHIKUMI Hiroki Tottori University, Hospital, Assistant, 医学部附属病院, 助手 (90283994)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
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| Keywords | humidifier / relative humidity / chronic respiratory failure / bacterial culture / bacterial contamination / oxygen concentration / hollow fiber |
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| Research Abstract |
It is well known that conventional bubbling humidifiers are capable of producing micro-aerosols contaminated with bacteria. We developed a unique humidifier named as membrane humidifier that does not require an external water supply. This new system obtains moisture from room air. We investigated the clinical and in vitro evaluation of membrane humidifier.
Ten patients with chronic pulmonary disease participated in the study. We evaluated the partial pressure of oxygen in arterial blood (PaOィイD22ィエD2) of 10 patients who used the new device. We conducted an in vitro study to determine whether the device could prevent the bacterial contamination of humidified-oxygen passed inside the hollow fibers was sampled into nutrient broth periodically for 10 days. We also compared the relative humidity of oxygen humidified by a membrane humidifier with that of oxygen humidified by a bubbling humidifier.
There was no significant difference between measured PaOィイD22ィエD2 while breathing oxygen humidified using a membrane humidifier and that while breathing oxygen humidified using a bubbling humidifier. Cultures of the humidified-oxygen passed through the hollow fibers were negative for bacteria. The membrane humidifier could produce well humidification.
The new device appeared to prevent bacterial contamination, and may help to reduce the risk of infection in patients at hospital and home.
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