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Mechanisms of the hypertrophy/hyperplasia of heart/vessels and the cardio-reno-protection to ischemia

Research Project

Project/Area Number 10670627
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

KOHZUKI Masahiro  University Hospital, Lecturer, 医学部・附属病院, 講師 (70234698)

Co-Investigator(Kenkyū-buntansha) KAMIMOTO Masahiro  University Hospital, Research Associate, 医学部・附属病院, 助手 (00271924)
SOMA Jun  University Hospital, Lecturer, 医学部・附属病院, 講師 (50301049)
YOSHIDA Kazunori  Graduate School of Medicine, Tohoku University, Research Associate, 大学院・医学系研究科, 助手 (90292218)
ONODERA Hiroshi  Graduate School of Medicine, Tohoku University, Associate Professor, 大学院・医学系研究科, j助教授 (20214207)
SATO Tokutaro  Graduate School of Medicine, Tohoku University, Professor, 大学院・医学系研究科, 教授 (70004687)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1999: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1998: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordschemokine / Wistar-Kyoto rat / SHR / ischemia / reperfusion / heart / Wistar-Kyoto Rat / GDNF / Hypoxia inducible factor / vascular endothelial growth factor / treadmill / losartan
Research Abstract

1. We assessed the renal benefits of cicletanine (CIC), a furopyridine derivative drug with diuretic and antihypertensive properties, in diabetic spontaneously hypertensive Izmo rats (SHR) and Wistar-Kyoto rats (WKY) with renal impairment. CIC has a renal-protective action, which is not related to improvement of diabetes and improvement of high blood pressure in diabetic WKY and diabetic SHR. The actions might be due to the reduction of intraglomerular capillary pressure or protection of the renal glomerular vascular endothelial cell / mesangial cell injury through stimulation of PGI2 generation or elimination of free radicals, although the mechanism remains to be further investigated.
2. Usefulness of the systemic hypertension induced by transient angiotensin II infusion in tumor therapy was established. The mechanism of the increased blood flow in tumor vessels is the decreased numbers of angiotensin II type A receptor in rat LY-80 and AH109A tumor and human gastric cancer which revea … More led by quantitative n vitro autoradiography.
3. We assessed the renal effects of mild to severe chronic treadmill exercise in the spontaneously hypertensive rats (SHR) remnant kidney model of chronic renal failure (CRF). Chronic treadmill exercise significantly attenuated the increase in proteinuria and in serum total cholesterol levels intensity-dependently. Moderate-Ex significantly and effectively protected against increases in the percentage of focal glomerular sclerosis (FGS). Enalapril, losartan and amlodipine significantly decreased blood pressure, further decreased proteinuria and the percentage of FGS similarly in the rats with moderate Ex. These results indicate that exercise does not worsen renal function and suggest that exercise have renal-protective actions in this model of rats. Moreover the antihypertensive therapy has synergic renal-protective effects in this model of rats.
4. Effects of intense exercise on renal oxygen consumption and urinary sodium excretion were assesses. Less

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (46 results)

All Other

All Publications (46 results)

  • [Publications] Kuge N: "Relation between natriuresis and urinary excretion of hydrogen peroxide"Free Radical Research. 30. 119-123 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kohzuki M: "Renal-protective effect of non-de pressor dose of cicletanine in streptozotocin diabetic rats"Journal of Hypertension. 17. 695-700 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoshida T: "Physical and Psychological Improvements after Phase II Rehabilitation in Patients with Myocardial Infarction"Nursing and Health Sciences. 1. 163-170 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kohzuki M: "Effects of chronic exercise on renal function in rats with chronic renal failure"Medicine and Science in Sports and Exercise. 31. S100 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kohzuki M: "Effects of intense exercise on renal oxygen consumption and urinary sodium excretion"Medicine and Science in Sports and Exercise. 31. S323 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kohzuki M: "Decreased binding sites of angiotensin II in rat LY-80 and AH109A tumor and human gastric cancer using quantitative in vitro autoradiography"International Angiology. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoshida K, et al.: "Angiotensin-converting enzyme inhibition and salt in experimental myocardial infraction"J Cardiovasc Pharmacol.. 32. 357-365 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kohzuki M, et al.: "Chronic effects of FR139317 and enalapril on renal failure rats with moderate exercise"J Cardiovasc Pharmacol.. 31 (Suppl 1). 486-488 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kohzuki M, et al.: "Endothelin receptors and angiotensin II receptors in tumor tissue"J Cardiovasc Pharmacol.. 31 (Suppl 1). 531-533 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Jiang Z-L, et al.: "Muscle damage induced by experimental hypoglycemia"Metabolism. 47. 1472-1476 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kuge N, et al.: "Relation between natriuresis and urinary excretion of hydrogen peroxide"Free Rad Res. 30. 119-123 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kohzuki M, et al.: "Renal-protective effect of non-depressor dose of cicletanine in streptozotocin diabetic rats"J Hypertens. 17. 695-700 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kuge N, et al.: "Determination of urinary hydrogen peroxide excretion"Free Rad Res. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoshida T, et al.: "Physical and Psychological Improvements after Phase II Cardiac Rehabilitation in Patients with Myocardial Infarction"Nursing and Health Sciences. (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kohzuki M, et al.: "Decreased binding sites of angiotensin II in rat LY-80 and AH109A tumor and human gastric cancer using quantitative in vitro autoradiography"International Angiology. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kohzuki M, et al.: "Renal-protective effect of non-depressor dose of cicletanine in diabetic spontaneously hypertensive rats"Am J Hypertens. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoshida K, et al.: "A case of lobenzarit disodium-induced hyperkalemia successfully treated with fludrocortisone acetate"Clin Exp Nephrol. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kohzuki M, et al.: "Rehabilitation to A Hepatopulmonary Syndrome Patient Who had Living-Related Orthotopic Liver Transplantation"Archives Physical Med & Rebabilitation. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kuge N.: "Relation between natriuresis and urinay excretion of hydrogen peroxide"Free Radical Resarch. 30. 119-123 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kohzuki M.: "Renal-protective effect of non-depressor dose of cicletanine in streptozotocin diabetic rats"Journal of Hypertension. 17. 695-700 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yoshida T.: "Physical and Psychological Improvements after Phase II Cardiac Rehabilitation in Patients with Myocardial Infarction"Nursing and Health Sciences. 1. 163-170 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kohzuki M.: "Effects of chronic exercise on renal function in rats with chronic renal failure"Medicine and Science in Sports and Exercise. 31. S100 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kohzuki M.: "Effects of intense exercise on renal oxygen consumption and urinary sodium excretion"Medicine and Science in Sports and Exercise. 31. S323 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kohzuki M.: "Decreased binding sites of angiotensin II in rat LY-80 and AH109A tumor and human gastric cancer using quantative in vitro autoradiography"International Angiology. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kohzuki M: "Chronic effects of FR139317 and enalapril on renal failure rats with moderate exercise." Journal of Cardiovascular Pharmacology. 31(Suppl1). 486-488 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kohzuki M: "Endothelin receptors and angiotensin II receptors in tumor tissue." Journal of Cardiovascular Pharmacology. 31(Suppl1). 531-533 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kohzuki M: "Renal-protective effect of non-depressor dose of cicletanine in streptozotocin diabetic rats." Journal of Hypertension. in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kohzuki M: "Decreased binding sites of angiotensin II in rat LY-80 and AH109A tumor and human gastric cancer using quantitative in vitro autoradiography." International Angiology. in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yoshida K: "Angiotensin-converting enzyme inhibition and salt in experimental myocardial infarction" Journal of Cardiovascular Pharmacology. 32. 357-365 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yoshida K: "Hypotensive effect of ZD7155, an angiotensin II receptor antagonist, parallels receptor occupancy in two-kidney, one clip Goldblatt hypertensive rats." Journal of Hypertension. 16. 645-655 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yoshida K: "Effect of chronic neutral endopeptidase inhibition on cardiac hypertrophy after experimental myocardial infarction" Japanese Circulation Journal. 62. 680-686 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yoshida K: "Inhibition of kidney neutral endopeptidase after administration of the neutral endopeptidase inhibitor candoxatril : quantitation by autoradiography." Journal of Cardiovascular Pharmacology. 32. 702-708 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Jiang Z-L: "Muscle damage induced by experimental hypoglycemia." Metabolism. 47. 1472-1476 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kuge N: "Detemination of urinary hydrogen peroxide excretion." Free Radical Research. in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kuge N: "Relation between natriuresis and urinary excretion of hydrogen peroxide." Free Radical Research. in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yoshida T: "Physical and Psychological Improvements after Phase II Cardiac Rehabilitation in Patients with Myocardial Infarction." Nursing and Health Sciences. in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 上月正博: "高血圧症(I)-高血圧症の診断と治療方針-" 臨床リハビリテーション医学. 7. 160-166 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 上月正博: "高血圧症(II)-脳卒中患者の血圧管理-" 臨床リハビリテーション医学. 7. 278-281 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 上月正博: "循環器・高血圧のリハビリテーション。" カレントテラピー. 16. 90-103 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 上月正博: "脳卒中患者における虚血性心疾患の発病の背景" リハビリテーション医学. 35. 209-212 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 上月正博: "慢性腎不全の腎・血管病変に対する降圧薬及び運動の効果の解析と相互作用の解明" 宮城県腎臓協会会報. 10. 79-80 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 上月正博: "呼吸不全の運動療法。" 医学のあゆみ. 185. 496-497 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 吉田俊子: "心筋梗塞回復期リハビリテーションにおけるライフスタイル改善効果。" 臨床リハビリテーション医学. 7. 760-763 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 後藤葉子: "慢性肺気腫患者の身体的因子とQOLとの関連。" 日本呼吸管理学会雑誌. 印刷中. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 上月正博: "運動障害者における心疾患への対応。虚血性心疾患が問題となる場合 II慢性期。" 臨床リハビリテーション医学. 8(印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 呉 学敏: "慢性運動負荷が高血圧腎不全モデルラットの腎に及ぼす影響。" 日本腎臓学会誌. 印刷中. (1999)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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