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Quantitative Tissue Characterization of Valvular Disease Based Upon Acoustic Properties Measured by High-frequency Ultrasound

Research Project

Project/Area Number 10670664
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKagawa Medical University

Principal Investigator

SAKAMOTO Seiji  Kagawa Medical University Hospital, Second Department of Internal Medicine, Lecturer, 医学部・附属病院, 講師 (60253267)

Co-Investigator(Kenkyū-buntansha) SAKAMOTO Haruhiko  Kagawa Medical University, Second Department of Pathology, Professor, 医学部, 教授 (60106549)
SENDA Shoichi  Kagawa Medical University Hospital, Primary Care Medicine, Professor, 医学部・附属病院, 教授 (30145049)
MATSUO Hirohide  Kagawa Medical University, Second Department of Internal Medicine, Professor, 医学部, 教授 (90028514)
NOZAKI Shiro  Kagawa Medical University Hospital, Clinical Laboratory, Assistant Professor, 医学部・附属病院, 助手 (80243773)
MIZUSHIGE Katsufumi  Kagawa Medical University, Second Department of Internal Medicine, Associate Professor, 医学部・附属病院, 助教授 (90166009)
MASUGATA Hisashi  Kagawa Medical University Hospital, Second Department of Internal Medicine, Assistant Professor (70263910)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordssound speed / valvular tissue / elasticity / valvular regurgitation / acoustic microscopy / amyloidosis / 超音波 / 弁膜症 / 組織 / 大動脈弁 / 僧帽弁
Research Abstract

The purpose of the present study was to measure tissue sound speed and ultrasonic attenuation of cardiac valve using acoustic microscopy with high frequency ultrasound. Myocardial and valvular tissue density positively correlated with the tissue sound speed measured by acoustic microscopy. Therefore, according to the equation K=ρ c^2, where K is the bulk modulus, ρ is the density, and c is the sound speed of tissue, myocardial and valvular tissue sound speed data enables us to evaluate tissue elasticity without measuring tissue density directly. In order to assess die physical properties of mitral valve tissue by evaluating the sound speed of the mitral valve tissue in cardiac amyloidosis, mitral valve specimens were obtained at autopsy from 20 control subjects without cardiovascular disease and from 20 patients with cardiac amyloidosis. The tissue sound speed was measured using acoustic microscopy. The patients with cardiac amyloidosis showing moderate mitral regurgitation demonstrated the greater reduction in the tissue sound speed than the patients with cardiac amyloidosis showing mild mitral regurgitation. The data suggest that the changes in physical properties of the MV tissue may be one of causes of mitral regurgitation in cardiac amyloidosis. Thus, tissue sound speed of cardiac valve measured by acoustic microscopy provides information regarding quantitative tissue characterization and pathophysiology in valvular disease.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Masugata H: "Comparison of left ventricular diastolic filling with myocyte bulk modulus using Doppler echocardiography and acoustic microscopy in pressure-overload left ventricular hypertrophy and cardiac amyloidocis."Clinical Cardiology. 23(2). 115-122 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masugata H: "Relationship between the acoustic propagation properties of the mitral valve and the severity of mitral regurgitation in patients with cardiac amyloidosis."J Am Coll Cardiol. 35(Suppl A). 523A (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masugata H: "Physical properties of the mitral valve tissue assessed by tissue sound speed in cardiac amyloidosis : relationship to the severity of mitral regurgitation."Ultrasound Med Biol. 26(7). 1191-1198 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masugata H: "Relationship between myocardial ti. ssue density measured by microgravimetry and sound speed measured by acoustic microscopy."Ultrasound Med Biol. 25(9). 1459-1463 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masugata H: "Tissue characterization of myocardlal cells by use of high- frequency acoustic microscopy : differential myocyte sound speed and its transmural variation in normal, pressure- overload hypertrophic, and amyloid myocardium."Angiology. 50(10). 837-845 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masugata H: "Evaluation of left atrial wall elasticity using acoustic microscopy."Angiology. 50(7). 583-590 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 1. Masugata Hisashi: "Physical properties of the mitral valve tissue assessed by tissue sound speed in cardiac amyloidosis : relationship to the severity of mitral regurgitation."Ultrasound Med Biol. 26(7). 1191-1198 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 2. Masugata Hisashi: "Comparison of left ventricular diastolic filling with myocyte bulk modulus using Doppler echocardiography and acoustic microscopy in pressure-overload left ventricular hypertrophy and cardiac amyloidosis."Clin Cardiol. 23(2). 115-122 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 3. Masugata Hisashi: "Relationship between myocardial tissue density measured by microgravimetry and sound speed measured by acoustic microscopy."Ultrasound Med Biol. 25(9). 1459-1463 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 4. Masugata Hisashi: "Tissue characterization of myocardial cells by use of high-frequency acoustic microscopy : differential myocyte sound speed and its transmural variation in normal, pressure-overload hypertrophic, and amyloid myocardium."Angiology. 50(10). 837-845 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 5. Masugata Hisashi: "Evaluation of left atrial wall elasticity using acoustic microscopy."Angiology. 50(7). 583-590 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 6. Mizushige Katsufumi: "Cyclic varlation of thickness in an age-related thick mitral valve observed by transthoracic echocardiography."Angiology. 50(9). 735-743 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 7. Lu Xin: "Evaluation of progression in nonrheumatic aortic valvular stenosis by scanning acoustic microscopy."Ultrasound Med Biol. 26(4). 563-569 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 8. Masugata Hisashi: "Tissue characterization of mitral valve using acoustic microscopy"J Cardiol. 31(Suppl I). 45-49 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsugata H: "Comparison of left ventricular diastolic filling with myocyte bulk modulus using Doppler echocardiography and acoustic microscopy in pressure-overload left ventricular hypertrophy and cardiac amyloidosis."Clinical Cardiology. 23(2). 115-122 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Matsugata H: "Relationship between the acoustic propagation properties of the mitral valve and the severity of mitral regurgitation in patients with cardiac amyloidosis."J Am Coll Cardiol. 35(Suppl A). 523A (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Masugata Hisashi: "Mitral valve tissue characterization using acoustic microscopy" Journal of Cardiology. 31(Suppl I). 45-49 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Lu Xin: "Image of aortic valve obtained by scanning acoustic microscopy" Ultrasound International. 4(4). 1-8 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Masugata Hisashi: "Evaluation of left atrial wall elasticity using acoustic microscopy" Angiology. (in press). (1999)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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