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Molecular analysis of hepatitis G virus and TT virus in pediatric population

Research Project

Project/Area Number 10670704
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionUniversity of Tsukuba

Principal Investigator

RYO Sumazaki  Univ. of Tsukuba, Dept. of Pediatrics, 臨床医学系, 助教授 (40163050)

Co-Investigator(Kenkyū-buntansha) AKIRA Matsui  Univ. of Tsukuba, Dept. of Pediatrics, 臨床医学系, 教授 (00159146)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2000: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1998: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsHepatitis G virus / Immunosuppression / Posttransfusion hepatitis / Blood products / Chronic hepatitis / Molecular epidemiology / TT virus / Community infection / 血友病 / TTウィルス / 遺伝子型 / 血液悪性腫瘍 / 免疫抑制 / C型肝炎 / G型肝炎
Research Abstract

Both hepatitis G virus (HGV) and TT virus (TTV) are transfusion-transmissible agent. Thus, we investigate both viruses at the same time in hemophilics and pediatric bone marrow transplant recipients. Concerning HGV infection, the objectives of our study was to clarify the prevalence and natural course in these pediatric patients. HGV are prevalent in hemophiliacs treated with unsterilized coagulation factor concentrates, however in contrast to hepatitis C virus Infection, spontaneous recovery was frequently observed in HGV infection (Br J Haematol 1998, 102 : 616-621). In children treated for hematological malignancy, these immunosuppressed patients can apparently recover from HGV infection without detectable anti-E2 antibody and some patients who supposedly recovered from HGV infection can nonetheless suffer exacerbation when subsequently immunosuppressed during chemotherapy or bone marrow trasplantation (Blood 1999, 93 : 721-727).
Next, we examined whether and how did TTV infect in children. The high incidence of TTV viremia in healthy population including small infants without transfusion made it clear for the virus initially identified as a transfusion-transmitted agent to transmit non-parenterally more frequently (Lancet 1998, 9136 : 1309-1310). We also found a higher prevalence of active TTV infection in our haemophiliac cohort than that in age-matched normal control and suspect the possible transmission of TTV through heat-treated blood products (Lancet 1998, 9136 : 1308-1309).

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Osaki M, Sumazaki R.et al: "Natural course of HGV infection in haemophiliacs"Br.J Haematol. 102・2. 616-621 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sumazaki R et al: "Transfusion transmitted virus"Lancet. 352(9136). 1308-1309 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Osaki M, Sumazaki R et al: "Transfusion transmitted virus"Lancet. 352(9136). 1309-1310 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Osaki M, Sumazaki R et al: "Persistence and Clinical out come of hepatitis G virus infection in Pediatric bone marrow transplant recipients"Blood. 93・2. 721-727 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Chuan H, Sumazaki R et al: "Transfusion-transmitted virus infection in china : Prevalence in blood donors and in patients with liven disense"JGastroenterol Hepatol. 14・9. 899-903 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 須磨崎亮 他: "G型肝炎ウイルス感染と肝疾患"小児内科. 31・12. 1744-1748 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamada-Osaki M, Sumazaki R, Tsuchida M, Koike K, Fukushima T, Matsui A: "Persistence and Clinical Outcome of Hepatitis G Virus Infection in Pediatric Bone Marrow Transplant Recipients and Children Treated for Hematological Malignancy"Blood. 93. 721-727 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] He C, Nomura F, Yukimasa N, Itoga S, Yamada-Osaki M, Sumazaki R, Nakai T: "Transfusion-transmitted virus infection in China : Prevalence in blood donors and in patients with liver diseases"Journal of Gastroenterology and Hepatology. 14. 899-903 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamada-Osaki M, Sumazaki R, Kajiwara Y, Miyakawa T, Shirahata A, Matsui A: "Natural course of HGV infection in haemophiliacs"Br J Haematol. 102. 616-621 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sumazaki R, Yamada-Osaki M, Kajiwara Y, Shirahata A, Matsui A: "Transfusion transmitted virus"Lancet. 352(9136). 1308-1309 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamada-Osaki M, Sumazaki R, Noguchi E, Shibasaki M, Matsui A: "Transfusion transmitted virus"Lancet. 352(9136). 1309-1310 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Osaki M,Samazaki R et al: "Natural course of HGV infection in haemophiliacs"Br.J Haematol. 102・2. 616-621 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sumazaki R et al: "Transfusion transmitted virus"Lancet. 352(9136). 1308-1309 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] Osaki M,Sumazaki R et al: "Transfusion transmitted virus"Lancet. 352(9136). 1309-1310 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] Osaki M,Sumazaki R et al: "Persistence and clinical outcome of hepatitis G virus infection in pediatric bone marrow transplant recipients"Blood. 93・2. 721-727 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Chuan H,Sumazaki R et al: "Transfusion-transmitted virus infection in China : Prevalence in blood donors and in patients with liver disease"J Gastroenterol Hepatol. 14・9. 899-903 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 須磨崎亮 他: "G型肝炎ウイルス感染と肝疾患"小児内科. 31・12. 1744-1748 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sumazaki et al: "Transfusion transmitted virus"Lancet. 352. 1308-1309 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamada-Osaki et al: "Persistence and Clinical outcome of HGV infection"Blood. 93・(2). 721-727 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Osaki,MY,Sumazaki,R et al: "Natural course of HGV infection in haemophiliacs." British Journal of Haematology. 102・2. 616-621 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Osaki,MY,Sumazaki,R et al: "Persistence and clinical outcome of HGV infection in Pediatric BMT Recipien" Blood. 93・2. 721-727 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sumazaki,R,et al: "Transfusion transmitted virus" Lancet. 352・9132. 1308-1309 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Osaki,MY,Sumazaki,R et al: "Transfusion transmitted virus" Lancet. 352・9132. 1309-1310 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 大崎牧,須磨崎亮: "免疫抑制状態におけるHGV感染の自然歴" 肝臓. 39・8. 569-572 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 須磨崎亮 他: "HGV感染症の病態" 小児科診療. 61・12. 2181-2187 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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