| Project/Area Number |
10670711
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Saitama Medical School (1999)
福井医科大学 (1998) |
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Principal Investigator |
KONISHI Yukuo Saitama Medical School, Department of Pediatrics, professor, 医学部, 教授 (40135588)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1999: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1998: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | functional MRI / Visual cortex / infants / Perinatal brain Damage / 新生児高次脳機能 |
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| Research Abstract |
Purpose : Functional MRI (fMRI) with visual stimulation was evaluated in infants with periventricular leukomalacia (PVL), in order to examine the correlation of visual function, MR abnormalities and visual activation patterns.
Methods: 8 infants with PVL diagnosed with MRI within 6 months after birth and 8 infants without PVL (control group) were examined with multislice echoplanar fMRI on a 1 .5T MR -system. All infants were Intravenously sedated with pentobarbital 3-5mg/kg. Consecutive 100 gradient-echo echo planar data sets were acquired with TR/TE of 3000/50, a flip angle of 90, a FOV of 220, a 128 x 128 image matrix and a slice thickness of 5mm. Each data set contained consecutive 3 axial slices covering calcaline sulcus. An initial baseline phase of rest for 30 sec was followed by photic stimulation phase alternating with a rest phase, with a total of 10 phase per trial. Visual stimulation was performed with a flash light (8 Hg) project onto the eyelids.
Results : 8 infants without PVL showed a signal decrease in the visual cortex upon visual stimulation. On the other hands, 6 out of 8 infants with PVL showed no activation in visual cortex. These 6 infants had severe strabismus and could not follow objects at 6 months after birth. And all of them had sever cerebral palsy and mental retardation at two years of age. These findings suggested that brain fMRI is a useful method to evaluate the visual function in infants.
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