| Project/Area Number |
10670748
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | School of Medicine, Kyoto Prefectural University of Medicine |
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Principal Investigator |
SHIRAISHI Isao Kyoto Prefectural University of Medicine, Assistant Professor, 医学部, 助手 (80295659)
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|---|
| Project Period (FY) |
1998 – 1999
|
| Project Status |
Completed (Fiscal Year 1999)
|
| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1999: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1998: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | collagen III / knockout mouse / extracellular matrix / collagen type III / gene targetting |
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| Research Abstract |
Collagen type III is a fibrous collagen which is essential for maintaining elasticity of cardiovascular system. Liu et al. (Proc Natl Acad Sci USA94 ; 1852-1856 : 1997) have developed collagen type III knockout mouse by homologous recombination. In this project, we perform histopathological analysis of collagen type II KO mice, especially on cardiovascular system. We found that some homozygous offsprings showed subcutaneous, stomach, and pulmonary hemorrhage, and marked enlargement of the heart. However, they did not show any cardiac malformation. Further investigation is necessary to prove the consistency of these lesions.
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