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MELANOCYTE MIGRATION AND REPIGMENTAION OF VITILIGO AND GREY HAIR-REGULATING MECHANISMS OF MELANOCYTE MIGRATION IN EPIDERMIAL-FOLLICULAR UNIT-

Research Project

Project/Area Number 10670788
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionKobe University

Principal Investigator

HORIKAWA Tatsuya  KOBE UNIVERSITY SCHOOL OF MEDICINE, DEPARTMENT OF DERMATOLOGY, LECTURER, 医学部・附属病院, 講師 (00173633)

Co-Investigator(Kenkyū-buntansha) ARAKI Keishi  KOBE UNIVERSITY SCHOOL OF MEDICINE, DEPARTMENT OF DERMATOLOGY, ASSISTANT PROFESSOR, 医学部・附属病院, 助手 (10294224)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1999: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1998: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsmelanocyte / vitiligo / hair follicle / migration / ras / SHP-2 / IL-12 / melanoma / CD4^+T cell / melanocyte / ET-3 / 毛包 / piebaldism / 色素拡大 / ras
Research Abstract

We have shown that melanocytes migrate from grafted epidermis into surrounding depigmented epidπermis in piebald white pathces. Further, we confirmed that the depigmented hairs became pigmented and melanocytes also migrate into the hair follicles (Pigment Cell Research, 12 : 175-180, 1999). Ras-transfected melanocyte study revealed that activated ras is involved in the induction of melanocyte migration (Pigment Cell Research, 11 : 182, 1998). We next showed that SHP-2, a tyrosine phosphatase, plays an important role in cell locomotion, using dominant negative mutant. (Oncogene, 19 : 75-84, 2000). We showed a melanoma antigen D-1 was specifically distributed in the melanoma tissues from melanoma patients (J Derm Sci, 17 : 115-122, 1998). We also found that IL-18 synergistically induces tumor rejection with IL-12 which is locally secreted by IL-12 transfected B-16 melanoma cells in vivo (Cancer Incest, in press). Using this IL-12 transfected melanoma cells, we showed that CD4ィイD2+ィエD2 Tcell depletion induce both melanoma rejection and vitiligo-like depigmentation (Pigment Cell Research, suppl. 7 : 27, 1999). In this regards, we found that IL-12 promotes accesary function of epidermal Langerhans cells (J Derm Sci, 18 : 98-108, 1998). Our findings will provide a useful information in establishing a new strategy of the treatment for depigmented disorders.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Nagai, H. et al.: "Tissue distribution of a melanoma-associated antigen D-1 immunogeneic in patients with melanoma"J. Derm. Sci. 17. 115-122 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suemoto, Y. et al.: "IL-12 promotes the accessory functionof epdermal Lngerhans cells"J. Derm. Sci. 18. 98-108 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Horikawa, T. et al.: "Horizontal and vertial pigment spread nto surrounding piebald epidermis and hair fllicles after suction blister eipdermal grafting"Pigment Cell Res.. 12. 175-180 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Horikawa, T. et al.: "H-ras transfected murine melanocyte line melan-A shows higher motility and reversed proliferative resonse to phorbolester"Pigment Cell Res.. 11. 182 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Inagaki, K. et al.: "Roles for the protein tyrosine phsphatase SHP-2 in cytoskelton organization, cell adhesion, and cell migration revealed by overexpression of a dominant negatve mutant"Oncogene. 19. 75-84 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagai, H. et al.: "Anti-tumor effection on mouse inetanoma elicited by local secretion of interleukin-12 and their enhancement with interleukin-18"Cancer Invest.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀川 達弥: "今日の治療指針,多賀須幸夫他編,医学書院,東京"尋常性白斑. 1 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagai H, Hayashi Y, Wang W, Kako S, Horikawa T, Hayashibe K, and Ichihashi M: "Tissue distribution of a melanoma-associated antigen D-1 immunogenic in patients with melanoma"J Derm Sci.. 17. 115-122 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagai H, Hayashi Y, Wang W, Kako S, Horikawa T, Hayashibe K, Ichihashi M: "Tissue distribution of a melanoma-associated antigen D-1 immunogeneic in patients with melanoma"J Derm Sci. 17. 115-122 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suemoto Y, Ando O, Kurimoto M, Horikawa T, Ichihashi M: "IL-12 promotes the accessory function of epidermal Langerhans cells"J Derm Sci. 18. 98-108 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Horikawa T, Araki K, Tsuru K, Ueda M, Tsukamoto K and Ichihashi M: "H-ras transfected murine melanocyte line melan-A shows higher motility and reversedproliferative response to phorbolester"Pigment Cell Res. 11. 182 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Horikawa T, Nishino K, Mishima Y, Ichihashi M: "Horizontal and vertical pigment spread into surrounding piebald epidermis and hair follicles after suction blister epidermal grafting"Pigment Cell Res. 12. 175-180 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Inagaki K, Noguchi T, Motozaki T, Horikawa T, Fukunaga K, Tsuda M, Ichihashi M, Kasuga M: "Roles for the protein tyrosine phosphatase SHP-2 in cytoskeltal organization, cell adhesion, and cell migration revealed by overexpression of a dominant negative mutant"Oncogene. 19. 75-84 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagai H, Hara I, Horikawa T, Fujii M, Kurimoto M, Kamidono S, Ichihashi M: "Antitumor effects on mouse melanoma elicited by local secretion of interleukin-12 and their enhancement by treatment with interleukin-18"Cancer Invest. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Horikawa T et al: "Horizoutal and vertical pigment spread into surrounding piebald epidermis and hair follicles after suction blister epidermal grafting"Pigment Cell Research. 12. 175-180 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Inagaki K et al: "Roles for the protein tyrosine phosphatose SHP-2 in cytoskeltal organization cell adhesion,and cell migration revealed by overexpression of a dominart negootive mutaut"Oncogene. 19. 75-84 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nagai H et al: "Antitumor effects on mouse milanoma elicited by local secretion of interleukin-12 and their enhancement with interleukin-18"Cancer Invest.. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] Nagai H et al: "Induction of hair dipigmentation and melanoma rejection by CD4^+T cell depletion in vivo;A study using IL-12 transfested B-16 melanoma cells"Pigment Cell Research. suppl.7. 27 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 堀川達弥: "今日の治療指針,多賀須幸夫他編,医学書院,東京"尋常性白斑. 1 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] T.Horikawa,et al: "Horizontal and Vertical pigment spread into surrounding piebald epidermis and hair follicles after suction blister epidermal grafting." Pigment Cell Res.(in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Nagai,I.Hara,T.Horikawa et al.: "Anti-tumor effects on mouse melanoma elicited by local secretion of Interleukin-12 and their enhancement by treatment with interleukin-18." Cancer Invest.(in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Horikawa et al: "H-Ras-transfected murime melanocyte cell line melan-A shows higher motility and reversed proliferative responce to phorbor ester." Pigment Cell Res.11. 182 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] A.Ohashi,Y.Funasaka,T.Horikawa,et al: "Endothelin-3 enhances growth and migration of cultured normal human melanocytes,nevus cells and melanoma cells." J.Derm.Sci.16S1. S103 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] K.Araki,T.Horikawa,et al: "Analysis of the role small GTP binding protein rab3A in secretion of melanesomes in pigment cells" J.Derm.Sci.16S1. S100 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Horikawa et al: "A case of Hermansky-Pudlak syndrome." Pigment Cell Res.11. 393 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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