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MOLECULAR MECHANISMS AND CLINICAL APPLICATION OF ULTRAVIOLET A THERAPY

Research Project

Project/Area Number 10670801
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionNAGOYA CITY UNIVERSITY

Principal Investigator

MORITA Akimichi  NAGOYA CITY UNIVERSITY MEDICAL SCHOOL, DERMATOLOGY, ASSISTANT PROFESSOR, 医学部, 講師 (30264732)

Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 1999: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1998: ¥2,700,000 (Direct Cost: ¥2,700,000)
KeywordsULTRAVIOLET RADIATION / PHOTOTHERAPY / SKIN DISEASE / SCLEROSIS / APOPTOSIS / FAS / COLLAGEN / METALLOPROTEINASE
Research Abstract

The purpose of this study was to investigate the underlying mechanisms and the clinical application of UVA1 phototherapy for skin diseases, e.g., atopic dermatitis, cutaneous T cell lymphoma and systemic sclerosis. UVA1 can penetrate through the epidermis to the deep dermis. No apoptosis was induced in keratinocytes and fibroblasts with 30-50 J/cmィイD12ィエD1 of UVA1 (430-400), which easily mediated T cell apoptosis. UVA1 induced FASL surface expression in keratinocytes if they were treated with metalloprotease inhibitor. Soluble FASL (sFASL) was also detected in the supernatant of UVA1-irradiated keratinocytes. The supernatant mediated apoptosis of FAS-expressing T cells with the treatment of the supernatant, which was partially inhibited with FASL antibody. The result suggested that sFASL from UVA1-irradiated keratinocytes mediated apoptosis of the infiltrating T cells in the lesion through paracrine mechanism. In fibroblasts, UVA1 upregulated metalloprotease (MMP)1, 3 but not TIMP-1, 3. It suggested that UVA1 might be effective for fibrous diseases, e.g., scleroderma. Based on the in vitro results, UVA1 therapy was attempted for the treatment of cutaneous malignant T cells and systemic sclerosis. The therapeutic effectiveness was found in both diseases.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Heidi Plettenberg: "Ultraviolet A-1(340-400 nm) phototherapy for cutaneous T cell lymphoma"Journal of America Academy of Dermatology. 41. 47-50 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Akimichi Moria: "Ultraviolet A-1 (340-400 nm) Phototherapy for scleroderma in systemic sclerosis"Journal of American Academy of Dermatology. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Lei Yin: "Alterations of extracellular matrix induced by tobacco smoke extra"Archives of Dermatological Research. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Jean Krutmann: "Mechanisms of ultraviolet (UV) B and UVA phototherapy"Journal of Investigative Dermatology Symposium Proceedings. 4. 70-72 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 森田明里: "紫外線と細胞応答"蛋白質 核酸 酵素. 44. 2517-2522 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 森田明里: "皮膚疾患に対する紫外線療法の今後"日本臨床皮膚科医学会雑誌. 63. 11-16 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Akimichi Morita: "Methods in enzymology, Singlet oxygen, UV-A & Ozone"Academic Press(L. Packer, H. Sies, eds)(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Jean Krutmann: "Dermatologic Phototherpy"Springer(J. Krutmann, H. Honigsmann, PR. Bergstresse, CA. Elners, eds)(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Heidi Plettenberg Helger Stege, Thomas Ruzicka, Yoko Hosokawa, Takuo Tsuji, Akimichi Morita, jean Krutmann: "Ultraviolet A-1 (340-400nm) phototherapy for cutaneous T cell lymphoma"Journal of American Academy of Dermatology. 41. 47-50 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Akimichi Morita, Keiko Kobayashi, Iwao Isomura, Takuo Tsuji, Jean krutmann: "UltravioletA-1 (340-400 nm) phototherapy for systemic sclerosis"Journal of American Academy of Dermatology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Lei Yin, Akimichi Morita and Takuo Tsuji: "Alterations of extracellular matrix induced by tobacco smoke extra"Archives of Dematological Research. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Jean Krutmann, Akimichi Morita: "Mechanisms of ultraviolet (UV) B and UVA phototherapy"Journal of Investigative Dermatology Symposium Proceedings. 4. 70-72 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Akimichi Morita: "Ultraviolet-mediated cellular respose"Tanpakushitsu Kakusan Koso. 44(15 Suppl). 2517-22 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Akimichi Morita and Jean Krutmann: "UVA radiation-induced apoptosis."Methods in Enzymology, Singlet oxygen, UV-A & Ozone, Academic Press (L. Packer, H. Sies, eds). (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Jean Krutmann and Akimichi Morita: "Photo(chemo)therapy of atopic dermatitis."Dermatologic Phototherapy, Springer (J. Krutmann, H. Honigsmann, PR. Bergstresse, CA. Elners, eds). (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Heidi Plettenberg: "Ultraviolet A-1 (340-400nm) phototherapy for cutaneous Tcell lymphoma"Journal of American Academy of Dermatology. 41. 47-50 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Akimichi Morita: "Ultraviolet A-1 (340-400nm) phototherapy for seleroderma in systemic sclerosis"Journal of American Academy of Dermatology. (印刷中).

    • Related Report
      1999 Annual Research Report
  • [Publications] Lei Yin: "Alterations of extracellular matrix induced by tobacco smoke extra"Archives of Dermatology Research. (印刷中).

    • Related Report
      1999 Annual Research Report
  • [Publications] Jean Krutmann: "Mechanisms of ultraviolet(UV)B and UVA phototherapy"Journal of Investigative Dermatology Symposium Proceedings. 4. 70-72 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 森田明理: "紫外線と細胞応答"蛋白質 核酸 酵素. 44. 2517-2522 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 森田明理: "皮膚疾患に対する紫外線療法の今後"日本臨床皮膚科医学会雑誌. 63. 11-16 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Akimichi Morita: "Methods in Enzymology, Singletoxygen, UV-A&Ozone"Academic Press(L.Packev, H.Sies eds)(印刷中).

    • Related Report
      1999 Annual Research Report
  • [Publications] Jean Krutmann: "Dermatologic Phototherapy"Springer(J.Krutmann,H.Honigsmann,PR.Bargstressen,CA.Elners,eds)(印刷中).

    • Related Report
      1999 Annual Research Report
  • [Publications] Heidi Plettenberg: "Ultrariolet A-1(340-400nm)phototherapyfarcutaneous T cell lymphoma" Journal of American Academy of Permatology. (印刷中).

    • Related Report
      1998 Annual Research Report
  • [Publications] Akimichi Morita: "Methods in Enxymology, Sigletoxygen, UV-A & Ozone" Academic Press (L.Packer, H.Sies eds) (印刷中),

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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