| Project/Area Number |
10670819
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | TOHOKU UNIVERSITY |
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Principal Investigator |
ITOH Masatoshi Division of Nuclear Medicine, Cyclotron Radioisotope Center, Tohoku University, Professor, サイクロトロンRIセンター, 教授 (00125501)
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| Co-Investigator(Kenkyū-buntansha) |
KUMANO Hiroaki School of Medicine, Human Behavioral Science, Tohoku University, Assistant Lecturer, 医学系研究科, 助手 (90280875)
KUBOTA Kazuo Division of Functional Imaging, Research Institute for Cancer and Aging, Tohoku University, Associate Professor, 加齢医学研究所, 助教授 (40161674)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1999: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1998: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Positron Emission Tomography / PET / Cerebral Metabolism / Cancer / Depression / Brain Function / 大脳辺縁系 |
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| Research Abstract |
Patients suffering from malignant disease are very prone to develop severe psychosomatic trauma due to the devastating nature of the ailment and aggressive treatment approach. Our study was aimed to document the psycho-psychiatric abnormalities developed in patients suffering from cancer using brain imaging technique. Brain images of cancer and benign patients were taken by positron emission tomography (PET) after infusion of [18F]-fluoro-deoxy-glucose as a tracer. The imaging results were compared between the cancer patients and the patients suffering a benign disease. The data were analyzed using statistical parametrical mapping technique (SPM96) developed by Friston et al (London, U.K.).
Our results have well illustrated the following imaging findings in the brain substrates. (1) Cancer patients have shown regional metabolic abnormality in the limbic structures of the brain with a remarkable decrement and noticeable decline was observed also in the frontal cortex. (2) This metabolic decline has shown some noted correlation with the course of treatments. It was more widely and significantly distributed in patients studied at their initial admission to a hospital prior to application of any specific treatment. Subsequently, the regions were regressed markedly after the completion of the therapeutic regimen of chemotherapy and/or radiation therapy. However, similar extensive metabolic abnormalities were again noted in those patients in whom the cancer had recurred. (3) We have speculated that these abnormalities were strongly associated with psychological factors such as depressive and anxiety disorders which also was later confirmed by asking a standard psychological questionnaire.
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