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Clinical and histopathological research on radiation therapy for early stage non-small cell lung cancer

Research Project

Project/Area Number 10670826
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionGunma University, School of Medicine

Principal Investigator

HAYAKAWA Kazushige  Gunma University School of Medicine, Assistant Professor, 医学部, 講師 (70114189)

Co-Investigator(Kenkyū-buntansha) HASEGAWA Masatoshi  Gunma University School of Medicine, Assistant Professor, 医学部, 講師 (50251111)
NIIBE Hideo  Gunma University School of Medicine, Professor, 医学部, 教授 (90008293)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
KeywordsNon-small cell lung cancer / Early stage disease / Radiation therapy / Brachytherapy / Stereotactic radiotherapy / p53 / Apoptosis / FDG-PET / 肺癌 / かん関連遺伝子 / 放射線感受性 / 免疫組織化学 / 小線源治療
Research Abstract

1) The effectiveness of high dose rate (HDR) endobronchial brachytherapy for roentgenographically negative carcinoma of the bronchus was prospectively evaluated. In our department, 14 lesions in 12 patients (11 male, one female) were treated with a combination of external radiotherapy and HDR endobronchial brachytherapy. Radiation dose was 40 Gy in 20 fractions for external radiotherapy. Endobronchial brachytherapy consisted of 10-25 Gy with 5 Gy/fr and the dose reference point varied 5-10 mm radius from the center of the applicator each according to a diameter of the bronchus. All patients had macroscopic complete response. Although the follow-up period ranged from 6 to 33 months with a median of 11 months, there were no patients with local progression. Radiation pneumonitis or other treatment-related complications have not been observed. These results suggested that the combination treatment of external radiotherapy and HDR brachytherapy can be used as curative intent for selected pa … More tients who have roentgenographically negative tumors limited to the bronchial wall without adjacent parenchymal extension or metastatic disease.
2) The outcome of limited field irradiation for medically inoperable patients with peripheral stage I non-small cell lung cancer (NSCLC) was analyzed to discuss the elective irradiation of regional lymph nodes. There was no significant difference in disease-specific survival between ten patients with the elective regional irradiation and 26 patients without the regional nodal irradiation. Only one patient without regional nodal irradiation developed an isolated regional failure. High-dose limited field RT is justified for medically inoperable patients with peripheral stage I NSCLC. The regional nodal irradiation can be omitted in these pulmonary compromised patients because of the low regional relapse rate.
3) The prognostic significance of nuclear p53 protein expression in survival and local control was investigated immunohistochemically in 36 patients with inoperable or unresectable non-small cell lung cancer who were treated with radiation therapy (RT). Response to RT was found in all p53 negative cases versus 72% in p53 positive cases (P<0.05). The 2-year survival rate for p53 negative cases was superior to that for p53 positive cases, although this difference was not statistically significant. The results suggested that p53 protein expression may be of predictive value on response to RT in non-small cell lung cancer.
4) We designed the current prospective study to evaluate FDG PET in the detection of recurrent or residual tumors in patients who had undergone definitive radiation therapy (RT) for primary lung cancer. With a standardized uptake value (SUV) 【greater than or equal】 3 used for detecting recurrent lesion, sensitivity, specificity, and accuracy were 75%, 100%, and 89%, respectively. PET may be useful for distinguishing recurrent lesion from postradiation changes. Less

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] Hayakawa K.: "Comparison of effects of doxorubicin and radiation on p53-dependent apoptosis in vivo"Oncology Report. 7. 267-270 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hayakawa K.: "Limited field irradiation for medically in operable patients with peripheral stage I NSCLC"Lung Cancer. 26(3). 137-142 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suzuki Y.: "In vivo study of radiosensitizing effect of hypoxic cell radiosensitizer PR-350 on a human SCLC"Anticancer Res.. 19(5B). 3993-4000 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mitsuhashi N.: "Cancer in patients aged 90 years or older : Radiation therapy"Radiology. 211(3). 829-833 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hayakawa K.: "The prognostic significance of immunohisto chemically detected p53 protein expression in NSCLC treated with radiation therapy"Anticancer Res.. 18(5B). 3685-3688 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hayakawa K.: "Radiation therapy for elderly patients with limited non-small cell lung cancer"J. Jpn. Soc. Ther. Radiol. Oncol.. 10(3). 223-228 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 早川和重: "肺癌治療におけるcontroversy"小林紘一. 10 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hayakawa, K., Hasegawa, M., Niibe, H., et al.: "Comparison of effects of doxorubicin and radiation on p53- dependent apoptosis in vivo."Oncology Rep. 7. 267-270 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hayakawa, K., Mitsuhashi, N., Niibe, H., et al.: "Limited field irradiation for medically inoperable patients with peripheral stage I non-small cell lung cancer."Lung Cancer. 26(3). 137-142 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mitsuhashi, N., Hayakawa, K., Niibe, H., et al.: "Cancer in patients aged 90 years or older : radiation therapy."Radiology. 211(3). 829-833 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suzuki, Y., Hasegawa, M., Hayakawa, K., Niibe, H., et al.: "In vivo study of radiosensitizing effect of hypoxic cell radiosensitizer PR-350 on a human small cell lung cancer."Anticancer Res. 19(5B). 3993-4000 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Saito, Y., Hasegawa, M., Hayakawa, K., Niibe, H., et al.: "Apoptosis and appearance of Trp53-positive micronuclei in murine tumors with different radioresponses in vivo."Radiat Res. 152(5). 462-467 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sakurai, H., Mitsuhashi, N., Hayakawa, K., Niibe, H., et al.: "Interaction between low dose-rate irradiation, mild hyperthermia and low-dose caffeine in a human lung cancer cell line."Int J Radiat Biol. 75(6). 739-745 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hayakawa, K., Mitsuhashi, N., Niibe, H., et al.: "Radiation therapy for elderly patients with limited non-small cell lung cancer."J Jpn Soc Ther Radiol Oncol. 10(3). 223-228 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hayakawa, K., Mitsuhashi, N., Niibe, H., et al.: "The prognistic significance of immunohistochemically detected p53 protein expression in non-small cell lung cancer treated with radiation therapy."Anticancer Res. 18(5B). 3685-3688 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Saito, Y., Mitsuhashi, N., Hayakawa, K., Niibe, H., et al.: "Prognostic value of pretreatment serum carcinoembryonic antigen and squamous cell carcinoma antigen levels for patients with stage I-III non-small cell lung cancer treated with radiation therapy alone."Int J Clin Oncol. 3(1). 27-30 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sakurai, H., Mitsuhashi, N., Niibe, H., et al.: "Cytotoxic enhancement of low dose-rate irradiation in human lung cancer cells by mild hyperthermia."Anticancer Res. 18(4A). 2525-2528 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Saito, Y., Mitsuhashi, N., Hayakawa, K., Niibe, H., et al.: "Cytotoxic effect of paclitaxel (taxol) either alone or in combination with irradiation in two rat yolk sac tumor cell lines with different radiosensitivities in vitro."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hayakawa,K.: "Comparison of effects of doxorubicin and radiation on p53-dependent apoptosis in vivo"Oncology Report. 7. 267-270 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hayakawa,K.: "Limited field irradiation for medially inoperable patients with peripehral stage I NSCLC"Lung Cancer. 26(3). 137-142 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Suzuki, Y.: "In vivo study of radiosensitizing effect of hypoxic cell radiosensitizer PR-350 on a humanSCLC"Anticancer Res.. 19(5B). 3993-4000 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mitsuhashi,N.: "Cancer in patients aged 90 years or older:Radiation therapy"Radiology. 211(3). 829-833 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hayakawa,K.: "The prognostic significance of immunohistochemically detected p53 protein expression in NSCLC treate with RT"Anticancer Res.. 18(5B9. 3685-3688 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hayakawa,K.: "Radiation therapy for elderly patients with limited non-small cell lung cancer"J. Jpn. Soc. Ther. Radiol. Oncol.. 10(3). 223-228 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 早川 和重: "肺癌治療におけるcontroversy"小林 鉱一. 10 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hayakawa K,Hasegawa M,Niibe H,et al.: "The prognostic significance of immunohistochemically detected p53 protein expression in non-small cell lung cancer treated with mchatron therogy." Anticancer Res.18・513. 3685-3688 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hayakawa K,Niibe H,et al.: "Radiation thenapy for eldevly patients with limited non-small cell lung cancer" J Jpn Soc Ther Radiol Orcol. 10・3. 223-228 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hayakawa K,Hasegawa M,Niibe H,et al.: "Radiotherapentic management of brain metrstases from breast cancer" Breast cancer. 5・2. 149-154 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Saito Y,Hayakawa K,Niibe et al.: "Prognostic value of pretreatment serum cavcinoenbryoic antigen and sguamous cell carcinome antigen levels for patients with stage I-III non small" Int J Clin Oncol. 3・1. 27-30 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mitsuhashi H,Hayakawa K,et al.: "Clinicel FDG-PET in diagnosis and evaluation of radshon response of patients with nasophergngeal tumon" Anticancer Res. 18・4B. 2827-2832 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Furuta M,Hayakawa K,et al.: "Malignent newro endocruhe trmon presanting amge medasnnel mass controlled with mdiation thereng" Lung cencer. 22.1. 55-58 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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