| Project/Area Number |
10670841
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Fukui Medical University |
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Principal Investigator |
TAKAHASHI Norio Fukui Medical University, Medical Hospital, Lecturer, 医学部附属病院, 講師 (10197163)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Masanori Fukui Medical University, Medical Hospital, Lecturer, 医学部附属病院, 講師 (00166969)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1999: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1998: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | C-11 acetate / F-18 FDG / Positron emission tomography (PET) / Prostate cancer / NO |
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| Research Abstract |
We introduced carbon-11(C-11) acetate PET for positive imaging of prostate cancer (PC) and evaluated the usefulness of C-11 acetate PET in comparison with FDG PET. Seventeen patients with PC underwent both C-11 acetate and F-18 FDG PET and one patient with benign prostate hyperplasia (BPH) underwent only C-11 acetate PET. C-11 acetate PET images of BPH showed faint uptake in the prostate and radioactivity in the urinary bladder was negligible. C-11 acetate PET visualized primary PC and its metastases in the pelvic region and sensitivity of primary lesions of C-11 acetate PET was superior to that of F-18 FDG PET. C-11 acetate uptake in the PC reflected clinical therapy response. From basic study using tumor cell lines, fibroblast, C-14 acetate and H-3 thymidine, it was found that C-14 accumulation in tumor cells was due to the anabolic pathway of acetate, and refrected the growth activity. Accordingly, C-11 acetate might be appropriate for estimating the growth activity of tumor cells. C-11 acetate PET is expected to be a simple and useful method for positive imaging of the primary PC and its metastases.
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