• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Research for Pathophysiology of Diffuse Cerebral White Matter Disease -Evaluation with MRI of Autopsied Brain and Diffusion Weighted MRI-

Research Project

Project/Area Number 10670850
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionTottori University

Principal Investigator

OGAWA Toshihide  Tottori University, Radiology, Professor, 医学部, 教授 (00125709)

Co-Investigator(Kenkyū-buntansha) SUGIHARA Shuji  Tottori University, Radiology, Staff, 医学部, 助手 (60291465)
KODAMA Fumiko  Tottori University, Radiology, Staff, 医学部, 助手 (50304225)
KINOSHITA Toshibumi  Tottori University, Radiology, Assistant Professor, 医学部, 講師 (70314599)
OHAMA Eisaku  Tottori University, Neuropathology, Professor, 医学部, 教授 (50018892)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2000: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1998: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsMRI / diffusion weighted image / leuko-araiosis / cerebrovascular disease / senile dementia of Alzheimer type / Creutzfeldt-Jakob Disease
Research Abstract

1. We performed postmortem MR examinations of 95 brains and compared them to the histology of the whole brain microscopic sections. Diffuse white matter lesions were observed in 12 brains with Alzheimer disease, Binswanger disease, Creutzfeldt-Jakob disease, intravascular lymphomatosis, and Parkinson's disease. While diffuse white matter lesions were observed around the periventricular regions in the Binswanger disease, convolutional white matter and U-fibers were relatively preserved. In the Alzheimer disease, loss of myelinated fibers and gliosis was marked in the temporal subcortical white matter and extreme capsule and was relatively mild in the frontal and parietal subcortical white matter. MR imaging clearly demonstrated such white matter lesions with or without U-fiber involvement observed by histological examination. 2. Diffusion weighted MR imaging was performed in 5 control subjects, 8 patients with Alzheimer's disease (AD) and 8 patients with Binswanger type vascular dementia (VD). Mean values of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were calculated in the genu and splenium of the corpus callosum, anterior and posterior cerebral white matter. There were no statistically significant differences in ADC values of the trace image between the AD and controls in any regions. FA value of the posterior white matter in patients with AD was significantly lower than that of controls. FA value in the patients with VD was significantly lower than that of the AD and controls in any regions. In the VD group, FA value of anterior white matter was lower than that of posterior white matter. The fractional anisotropy may be useful in the differentiation diagnosis of VD from AD.

Report

(4 results)
  • 2001 Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 小川敏英, 木下俊文, 神波雅之, 杉原修司, 奥寺利男: "虚血性脳血管障害"INNER VISION. 14・9. 98-102 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 木下俊文: "知っておきたい虚血性脳血管障害の知識"画像診断. 19・6. 600-606 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 木下俊文, 小川敏英, 宮田元, 大濱栄作: "脳血管障害の画像診断-白質の変化-"中外医学社(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 小川敏英, 木下俊文, 杉原修司: "脳血管障害の画像診断 虚血性変化・脳梗塞,血管周囲腔とラクナ梗塞"中外医学社(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ogawa T, Kinoshita T, Kamba M, Sugihara S, Okudera T: "Ischemic cerebrovascular disease"INNER VISION. 14. 98-102 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kinoshita T: "Essential knowledge for diagnostic imaging of ischemic cerebrovascular disease, MRI"Jpn J Diagnostic Imaging. 19. 600-606 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kinoshita T, Ogawa T, Miyata M, Ohama E: "Imaging of cerebrovascular disease, changes of white matter"(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ogawa T, Kinoshita T, Sugihara S.: "Imaging of cerebrovascular disease, perivascular space vs lacunar infarct"(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 木下俊文,小川敏英,杉原修司,児玉富美子,小濱栄作 他: "Intravascular lymphomatosisの大脳白質病変のMRI所見-Binswanger病との相違点-"第30会日本神経放射線学会プログラム・抄録集. 129 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 木下俊文,小川敏英,宮田元,大濱栄作: "脳血管障害の画像診断-白質の変化-"中外医学社(印刷中).

    • Related Report
      2000 Annual Research Report
  • [Publications] 小川 敏英: "虚血性脳血管障害"INNERVISION. 14・9. 98-102 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 木下俊文: "知っておきたい虚血性脳血管障害の知識 MRI"画像診断. 19・6. 600-606 (1999)

    • Related Report
      1999 Annual Research Report

URL: 

Published: 1998-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi