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Quantification of morphological change of cerebral blood vessels using three-dimensional fractal analysis and magnetic resonance angiography

Research Project

Project/Area Number 10670855
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionEhime University

Principal Investigator

IKEZOE Junpei  Ehime University, Faculty of Medicine, Professor, 医学部, 教授 (70115989)

Co-Investigator(Kenkyū-buntansha) MIKI Hitoshi  Ehime University, Faculty of Medicine, Assisstant Professor, 医学部, 講師 (00229668)
MURASE Kenya  Osaka University, Faculty of Medicine, Professor, 医学部, 教授 (50157773)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2000: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordscerebral blood vessels / fractal analysis / quantification / morphological change / magnetic resonance / angiography / 磁気共鳴血管撮影法 / 三次元画像
Research Abstract

Magnetic resonance angiography (MRA) has currently played a useful role as a noninvasive method of surveying vascular anatomy. In this study, we developed an automated seeded region growing algorithm for extraction of blood vessles from MRA data. In the conventional region growing algorithm, the user must manually place a seed point within a large blood vessel and also input the segmentation threshold. Furthermore, these processes must be repeated with a different set of seeds and threshold until the satisfactory results are obtained. Thus, this method is time- consuming and the results obtained by this method are highly subjective to the user. With our algorithm, binary images were firstly generated by thresholding the original MRA data to roughly obtained images of blood vessels, and then the skeletons were used for region growing. Our method extracted blood vessels automatically and stably, and the segmentation leakage could be largely suppressed. In conclusion, our automated seeded region growing algorithm appears to be useful for extracting and displaying blood vessels.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (42 results)

All Other

All Publications (42 results)

  • [Publications] Murase K,Inoue T,Fujioka H,Ikezoe J: "An alternative approach to estimation of the brain perfusion index"European Journal of Nuclear Medicine. 26. 1333-1339 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nagao M,Murase K,Ichiki T,Ikezoe J: "Quantitative analysis of Technegas SPECT : evaluation of regional severity of emphysema"Journal of Nuclear Medicine. 41. 590-595 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nagao M,Murase K,Ichiki T,Ikezoe J: "Relationship between regional severity of emphysema and coronary heart disease"Annals of Nuclear Medicine. 14. 369-372 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Murase K,Inoue T,Fujioka H,Ikezoe J: "Double-injection method for sequentially measuring cerebral blood flow with N-isopropyl-(^<123>I) P-iodoamphtamine"Annals of Nuclear Medicine. 14. 441-452 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kikuchik,Murase K,Miki H,Ikezoe J: "Measurement of cerebral hemodynamics with perfusion weighted MR imaging"American Journal of Neuroradiology. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Murase K,Kikuchi K,Miki H,Ikezoe J: "Determination of arterial input function using fuzzy clustering for quantification of CBF"Journal of Magnotic Resonance Imaging. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 村瀬研也: "放射線機器工学(X線CT)"医歯薬出版(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 村瀬研也: "放射線機器工学(核医学機器)"医歯薬出版(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Murase K, Fujioka H, Inoue T, Ishimaru Y, Akamune A: "Measurement of blood radioactivity for quantification of cerebral blood flow"Journal of Nuclear Medicine Technology. Vol.26. 191-195 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Murase K, Mochizuki T, Kikuchi T, Ikezoe J: "Kinetic parameter estimation from compartment models using a genetic algorithm"Nuclear Medicine Communications. Vol.20. 925-932 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Murase K, Tsuda T, Mochizuki T, Ikezoe J: "Hepatic extraction fraction of hepatobiliary radiopharmaceuticals measured using spectral analysis"Nuclear Medicine Communications. Vol.20. 1041-1046 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Murase K, Inoue T, Fujioka H, Ishimaru Y, Akamune A: "An alternative approach to estimation of the brain perfusion index"European Journal of Nuclear Medicine. Vol.26. 1333-1339 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Mochizuki T, Murase K, Koyama Y, Higashino H, Doi M, Shimizu K: "Two-and three-dimensional CT ventricu-lography-a new application of helical CT"American Journal of Roentgenology. Vol.174. 203-208 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nagao M, Murase K, Ichiki T, Sakai S, Yasuhara Y, Ikezoe J: "Quantitative analysis of Technegas SPECT : evaluation of regional severity of emphysema"Journal of Nuclear Medicine. Vol.41. 590-595 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nagao M, Murase K, Ichiki T, Sakai S, Yasuhara Y, Ikezoe J: "Relationship between regional severity of emphysema and coronary heart disease"Annals of Nuclear Medicine. Vol.14. 369-372 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Murase K, Inoue T, Fujioka H, Yamamoto Y, Ikezoe J: "Double-injection method for sequentially measuring cerebral blood flow with N-isopropyl- (^<123>I) p-iodoamphetamine"Annals of Nuclear Medicine. Vol.14. 441-452 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kikuchi K, Murase K, Miki H, Kikuchi T, Sugawara Y, Ikezoe J, Ohue S: "Measurement of cerebral hemodynamics with perfusion weighted MR imaging : compared with pre-and post-acetazola-mide Xe-133 SPECT in cervical occlusive disease"American Journal of Neuroradiology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Murase K, Kikuchi K, Miki H, Shimizu T, Ikezoe J: "Determination of arterial input function using fuzzy clustering for quantification of cerebral blood flow with dynamic susceptibility contrast-enhanced MR imaging"Magnetic Resonance Imaging. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Murase K,Inoue T,Fujioka H,Ikezoe J: "An alternative approach to estimation of the brain perfusion index"European Journal of Nuclear Medicine. 26. 1333-1339 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nagao M,Murase K,Ichiki T.Ikezoe J: "Quantitative analysis of Technegas SPECT : evaluation of regional severity of emphysema"Journal of Nuclear Medicine. 41. 590-595 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nagao M,Murase K,Ichiki T,Ikezone J: "Relationship between regional sererity of emphysema and coronary heart disease"Annals of Nuclear Medicine. 14. 369-372 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Murase K,Inoue T,Fujioka H,Ikezoe J: "Double-injection method for sequentially measuring cerebral blood flow with N-isopropyl-(^<123>I) P-iodoamphetamine"Annuals of Nuclear Medicine. 14. 441-452 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kikuchi K,Murase K,Miki H,Ikezoe J: "Measurement of cerebral hemodynamics with perfusion Weighted MR imaging"American Journal of Neuroradiology. (印刷中).

    • Related Report
      2000 Annual Research Report
  • [Publications] Murase K,Kikuchi K,Miki H,Ikezoe J: "Determination of arterial input function using fuzzy clustering for quantification of CBF"Journal of Magnetic Resonance Imaging. (印刷中).

    • Related Report
      2000 Annual Research Report
  • [Publications] 村瀬研也: "放射線機器工学(X線CT)"医歯薬出版(印刷中).

    • Related Report
      2000 Annual Research Report
  • [Publications] 村瀬研也: "放射線機器工学(核医学機器)"医歯薬出版(印刷中).

    • Related Report
      2000 Annual Research Report
  • [Publications] Nagao M,Murase K,Yasuhara Y,Ikezoe J: "Quantitative analysis of pulmonary emphysema:three-dimeusional fratal analysis of SPECT tmages"Am J Roentgenol. 171. 1657-1663 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Murase K,Mochizuki T,Kikuchi T,Ikezoe J: "Kinetic parameter estimation from campactmact models using a genetic algorithin"Nucl Med Commun. 20. 925-932 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Murase K,Tsuda T,Mochizuki T,Ikezoe J: "Hepatic extraction fraction of hepactobiliarg radiopration ceuticals imasured using spectral analysis"Nucl Med Commun. 20. 1041-1046 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Murase K,Inoue T,Fujicka H,Ishimura Y,Akamune A: "An allernative approach to estimation of the brain perfusion index for measurement of cerebral blood flow"Eur.J Nucl Med. 26. 1333-1339 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mochizuki T,Murase K,Koyama Y,Higashino H,Doi M,Shimizu K: "Two-and three-dimensional CT-venticulogropy-a new application of helical CT"Am J Roentgenol. 174. 203-208 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nagao M,Murase K,Ichiki T,Sukai S,Yasuhara Y,Ikezoe J: "Quantitative analysis of Technegas SPECT:evaluation of regional severity of emphysema"Journal of Nuclear Medicine. (印刷中).

    • Related Report
      1999 Annual Research Report
  • [Publications] 村瀬研也: "放射線機器工学(X線CT)"医歯薬出版(出版予定). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 村瀬研也: "放射線機器工学(核医学機器)"(出版予定). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] M.Miyagawa,T.Mochizuki,K.Murase J.Takada J.Ikezoe: "Prognostic value of dypiridamole thallium myocardial scintigraply in patients with kawasaki disease" Circulation. Vol.98No.10. 990-996 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] K.Murase,H.Fujita,T.Inoue,Y.Ishimoto et al.: "Measurement of blood radioocticity for quantification of cerebral blood flow using a gamma camera" Journal of Nうclear Medicime Tecnology. Vol.26No.3. 191-195 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Nagao,K.Murase,Y.Yasuhara,J.Ikezoe: "Quantltative analysis of pulmomary emplysema:three-dimensional fractal analysis of SPECT images" American Journal of Roetgenalogy. Vol.171 No.26. 1657-1663 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Mochizuki,K.Murase H.higashino,Y.koyama et al: "Demonstration of acute myocardial infarction by sub-second spiral CT" Circulation. 印刷中. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Mochizuki,K.Murase Y.koyama,H.higashino: "LAD Stenosis detected by sub-secおond spiral CT" Circulation. 印刷中. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 都築,泉田,村瀬,村上,三木,池添: "MRI画像における血管の特徴抽出に関する研究" 電子情報通信学会中四国支部会誌. 印刷中. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 村瀬研也: "SPECT機能画像" メディカルビュー社, 186 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 村瀬研也: "脳のSPECT" 南江堂(印刷中), (1999)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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