| Project/Area Number |
10670856
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
KUWABARA Yasuo Kyushu University, Department of Radiology, Associate Professor, 医学部, 助教授 (30150436)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Masato Kyushu University, Department of Clinical Radiology, Assistant Professor, 医学部, 助手 (30304794)
YOSHIDA Tsuyoshi Kyushu University, Department of Clinical Radiology, Assistant Professor, 医学部, 助手 (40284509)
SASAKI Masayuki Kyushu University, Department of Clinical Radiology, Assistant Professor, 医学部, 助手 (40240907)
NAKAGAWA Makoto Kyushu University, Department of Clinical Radiology, senior resident, 医学部, 医員
|
|---|
| Project Period (FY) |
1998 – 1999
|
| Project Status |
Completed (Fiscal Year 1999)
|
| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1998: ¥1,200,000 (Direct Cost: ¥1,200,000)
|
|---|
| Keywords | positron emission tomography / 3D data acquisition / dopamine D2 receptor / C-11 raclopride / Parkinson's disease / L-DOPA therapy |
|---|
| Research Abstract |
We performed fundamental studies for 3D data acquisition by high resolution PET using a striatal phantom, and then measured both dopamine D2 receptor binding with C-11 raclopride and cerebral metabolic rate for glucose with F-18 FDG in normal volunteers and patients with neurodegenerative disorders. The subjects consisted 9 normal volunteers and 15 patients, including 7 patients with Parkinson's disease, 5 patient with multiple system atrophy (MSA), a patient with progressive supranuclear palsy (PSP), a patient with corticobasal degeneration and a patient with dystonia. Striatal D2 receptor binding was evaluated by the C-11 raclopride equilibrium method. Fundamental studies using striatal phantom revealed that accuracy of the 3D data acquisition mode was equal to that of 2 D data acquisition mode. In normal volunteers, the striatal/cerebellar uptake ratio gradually decreased with age at a rate of 1.4% year. The dopamine D2 receptor binding was normal or slightly increased in patients with early Parkinson's disease, while it slightly decreased in a patient with MSA and a patient with PSP. However, the differential diagnosis of the Parkinsonian patients by C-11 raclopride PET was thought to be difficult due to wide variation of the D2 receptor binding. The dopamine D2 receptor binding in L-DOPA responsive patients was significantly higher than that in L-DOPA resistant patients. All of patients, in whom both the striatal D2 receptor binding and glucose metabolism were preserved, showed good response to L-DOPA. Thus, simultaneous measurement of these parameters was useful for the prediction of response to the L-DOPA therapy.
|
