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Detection of Neuronal Loss in Alzheimer Disease Using Magnetization Transfer MR Imaging

Research Project

Project/Area Number 10670866
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionIwate Medical University

Principal Investigator

SASAKI Makoto  Iwate Medical University, Department of Radiology, Assistant Professor, 医学部, 講師 (80205864)

Co-Investigator(Kenkyū-buntansha) SONE Miyuki  Iwate Medical University, Department of Radiology, Assistant, 医学部, 助手 (00226713)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥2,900,000 (Direct Cost: ¥2,900,000)
KeywordsAlzheimer disease / magnetic resonance imaging / magnetization transfer / hippocampus / entorhinal cortex / fast spin echo / short inversion-time inversion recovery / 磁化移動効果
Research Abstract

Purpose: To evaluate changes related to the neuronal loss of the hippocampus and the entorhinal cortex in patients with early Alzheimer disease (AD) using high-resolution magnetization-transfer (MT) fast spin-echo (FSE), and fast short inversion-time inversion-recovery (FSTIR) techniques. Methods: Fifteen patients with AD including early stages and ten age-matched normal volunteers were prospectively examined by a 1.5 Tesla superconductive MR scanner (Signal Horizon Lx, GEMS). The pulse sequences we used were FSTIR 4000/120/36 (TR/Tl/Teff) sequence with original optimizations, and proton-density weighted (PDW) FSE 1000/24 (TR/Teeff) sequence with single and multislice acquisitions. In each case, 4 mm thick coronal images through mamillary bodies were obtained with a 17cm field of view and zero-interpolated 512x512 matrices. Signal intensities of the hippocampus, entorhinal cortex, cingulate gyrus, superior temporal gyrus, caudate nucleus, deep white matter, and CSF were measured in sin … More gle-slice and multislice PDW-FSE images. Measurement areas were manually determined on FSTIR images in which gray/white matter contrast was remarkable. The MT ratio (MTR) in each structure was calculated from signal intensities obtained on single/multislice PDW-FSE images, and was normalized by MTR in the caudate nucleus.
Results: In all of the cases, measurement areas were readily determined with guidance of FSTIR images. MTRs of the hippocampus and the entorhinal cortex in patients with AD were lower than the control group with statistical significance, whereas those of the other structures indicated no significant alterations.
Conclusion: We successfully measured MTRs of the hippocampus and the entorhinal cortex by a combination of single/multislice PDW-FSE and optimized FSTIR techniques. MTRs in the hippocampus and the entorhinal cortex were decreased in early AD, suggesting changes related to the neuronal loss. MT measurements using high-resolution FSE/FSTIR images may help early diagnosis of AD before visible atrophy occurs. Less

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 佐々木真理: "神経系のMR撮像法"日本磁気共鳴医学会誌. 19. 503-509 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 佐々木真理: "MRIによる灰白質内構造の描出"臨床放射線. 44. 1229-1234 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 佐々木真理: "MRIによるアルツハイマー病の画像解析"老年性痴呆研究会誌. 11. 59-61 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 佐々木真理: "臨床精神医学講座第10巻 精神科臨床における画像診断"中山書店. (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 佐々木真理: "臨床放射線化のコツと落とし穴2"中山書店. (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sasaki M: "MR imaging techniques in neuroradiology."Jap J Magn Reson Med. 19. 503-519 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sasaki M, et al: "MR imaging of substructures in deep gray matters and cerebral cortices."Jap J Clin Radiol. 44. 1229-1234 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sasaki M: "Radiologicai analysis of Alzheimer disease using MR imaging."Proc Jap Res Group Senile Dementia. 11. 59-61 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sasaki M:: "Alzheimer disease -MRI-, lmaging diagnoses in clincial psychiatry"Nakayama-shoten,(in press). (in press) (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sasaki M: "Optimization of scanning parameters in fast spin echo sequences, Tips and pitfalls in clinical radiology"Nakayama-shoten. 116-117 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 佐々木真理: "神経系のMRI撮像法"日本磁気共鳴医学会雑誌. 19. 503-519 (1997)

    • Related Report
      1999 Annual Research Report
  • [Publications] 佐々木真理,他: "MRIによる灰白質内構造の描出"臨床放射線. 44. 1229-1234 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 佐々木真理: "MRIによるアルツハイマー病の画像解析"老年期痴呆研究会誌. 11. 59-61 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 佐々木真理: "臨床精神医学講座第10巻 精神科臨床における画像診断「Alzheimer型痴呆-MRI」"中山書店 (印刷中). (2000)

    • Related Report
      1999 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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