| Project/Area Number |
10670874
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
HIGASHI Kotaro Kanazawa Medical University, Medical department, Associate professor, 医学部, 助教授 (50189750)
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| Co-Investigator(Kenkyū-buntansha) |
UEDA Yoshimichi Kanazawa Medical University, Medical department, Associate professor, 医学部, 助教授 (50271375)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | Lung cancer / Radiosensitivity / multidrug resistance / C-11 acetate / F-18 FDG / PET / Tc-99m MIBI / P-糖タンパク / C-11酢酸 |
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| Research Abstract |
C-11 acetate clearance from cancer cell may reflect oxidative metabolism of cancer cell. The purpose of this study was to assess correlations between C-11 acetate clearance and radiosensitivity or multidrug resistance in lung cancer. Correlations between FDG uptake, Tc-99m MIBI clearance and multidrug resistance were also assessed. Dynamic C-11 acetate PET study was performed to estimate C-11 acetate clearance from lung cancer. FDG PET was performed 40 min after injection. Tc-99m MIBI SPECT was performed 15 min and 3 hrs after injection. Radiation effect was estimated by CT study 4 weeks after full dose radiotherapy. Multidrug resistance was estimated by immunohistochemical staining using anti-P-glycoprotein in antibody (JSB-1). There were no significant correlations between C-11 acetate clearance and radiosensitivity or P-glycoprotein expression in lung cancer. However, there was a significant correlatitween FDG uptake and P-glycoprotein expression. Lung cancer with strong P-glycoprotein expression showed low FDG uptake. The Tc-99m MIBI clearance correlated with P-glycoprotein expression. Lung cancer with strong P-glycoprotein expression showed high Tc-99m MIBI clearance. These results indicate that both FDG uptake and Tc-99m MIBI clearance may reflect P-glycoprotein expression in lung cancer.
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