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Enhancement of hyperthermia by blocking of the Endtherial Cell grouwth factor receptor

Research Project

Project/Area Number 10670877
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionSuzuka University of Medical Science

Principal Investigator

HASEGAWA Talep  Suzuka University of Medical Science, Faculty of Health Science, Professor, 保健衛生学部, 教授 (80077784)

Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1999: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1998: ¥2,700,000 (Direct Cost: ¥2,700,000)
KeywordsHyperthermia / Vessl endtherial cells / Angiogenesis factor / Vivo-vitro assey / Anti-tumor effect / Angiogenesis / Receptor of angiogenesis factor / SCC-VII tumor / Vivo-vitro assey / SCC-VII腫瘍
Research Abstract

The tumor has large area of hypoxic fraction and low nutrition due to the low vascularity. So tumor tissue produce the vascular endotherial growth factor (VEGF) for angiogenesis. When give the hyperthermia treatment to the tumor, tumor vessels induce the heat damage and increase the hypoxic area. Therefore, the tumor tissue emit the VEGF and then VEGF combined with VEGF-Receptor (VEGF-R) of vessels. When inject the VEGF to near the tumor, the vessels start the angiogenesis to the area of the VEGF injection point. Also, tumor tissue receive the signals of anngiogenesis, and then start the tumor cell proliferation. But still low blood flow and low nutrition, so tumor can't cell proliferation of normal and occur the abnormal division, division delay and cell death. I couldn't cloning the VEGF and VEGF-R. But I extracted the VEGF fraction of the protein from the endotherial cells. When injected the VEGF fraction to near of the tumor, tumor shows the growth delay, and angiogenesis was occurred around injection of the area of VEGF fraction. It means that VEGF can enhance the hyperthermia effect, and useful for treatment of the brain infaction and other infaction disease.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (35 results)

All Other

All Publications (35 results)

  • [Publications] Ihlbong choi, YeunHwa Gu, Takeo Hasegawa, et al: "Malformation and Embryonic in ICR Mice after Mild Hyperthermia"JPN J Hyperthermic Oncology. 14(4). 235-243 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeo Hasegawa, YeunHwa Gu, Tohru Takahashi et al: "Influence of an Anesthetic(Pentobarbital) on Hyperthermic Effects"Research Report of Suzuka University of Medical Science.. No.5. 91-99 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeo Hasegawa, YeunHwa Gu, Ikukatu Suzuki et al.: "Increase of the blood flow in the tissues by direct current magnetic field"Research Report of Suzuka University of Medical Science.. No.5. 163-168 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeo Hasegawa, Toshikaki Nishiguchi, YeunHwa Gu et al.: "Increases in Blood Flow in Specific Organs after Stimulation of Pressure Point in the Soles"Research Report of Suzuka University of Medical Science.. No.5. 169-175 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeo Hasegawa, YeunHwa Gu, Hiroaki Ushiba et al.: "Non-invasive temperature monitoring using small coils during radio-frequency heating"Proceedings of the Korean Association for Radiation Protection Autumn Meeting (Tague,Korea, Oct.22.1999). Vol.1. 49-52 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeo Hasegawa, YeunHwa Gu, Takashi Hasegawa et al.: "Potentiation of Hyperthermic Effects Using Vasodilator (Hydralazine)"Proceedings of the Korean Association for Radiation Protection Autumn Meeting (Tague,Korea, Oct.22.1999). Vol.1. 79-82 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 長谷川武夫、具 然和、山本五郎: "難治癌への挑戦 ハイパーサーミアの臨床(編集 : 松田忠義、菅原 努、阿部光幸)"株式会社医療科学社. 445 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ihlbong Choi, YeunHwa Gu, Takeo Hasegawa et al: "Malformation and Embryonic Death in ICR Mice after Mild Hyperthermia."JNP.J.Hyperthermic Oncology.. Vol.14,No.4. 235-243 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeo Hasegawa, YeunHwa Gu, Tohru Takahashi et al.: "Influence of an Anesthetic (Pentobarbital) on Hyperthermia Effects."Research Reports of Suzuka University of Medical Science. No.5. 91-99 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeo Hasegawa, YeunHwa Gu, Ikukatsu Szuki, et al: "Increase of the blood flow in the tissues by direct current magnetic field."Research Reports of Suzuka University of Medical Science.. No.5. 163-168 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeo Hasegawa, Toshiaki Nishiguchi, YeunHwa Gu, et al: "Increases in blood flow in specific organs after stimulation of pressure point in the soles. -Comfirmation of the body surface temperature using thermographic images-."Research Reports of Suzuka University of Medical Science.. No.5. 169-175 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeo Hasegawa, YeunHwa Gu, Hiroaki Ushiba, et al: "Non-invasive temperature monitoring using small coils during radio-frequency heating."Proceedings of the Korean Association for Radiation Protection Autumn Meeting. Tague, Korea. October. 49-52 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeo Hasegawa, YeunHwa Gyu, Takashi Hasegawa, et al: "Potentiation of Hyperthermic Effects Using Vasodilator (Hydralazine)."Proceedings of the Korean Association for Radiation Protection Autumn Meeting. Tague, Korea. October. 79-82 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YeunHwa Gu, Takao Hasegawa, Hiroe Muto, et al: "The effects of MRI and X-radiation on ICR mouse embryos during Organogenesis."Proceedings of the Korean Association for Radiation Protection Autumn Meeting. Tague, Korea. October. 28-33 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sachio Suzuki, YeunHwa Gu, Ikukatsu Suzuki, Takeo Hasegawa et al: "The radiation protection effect of propolis to embryonic effects in ICR mice."Proceedings of the Korean Association for Radiation Protection Autumn Meeting. Tague, Korea. October. 18-22 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeo Hasegawa, YeunHwa Gu, Chang W.Song et al: "Increase in Tumor Oxygen Tension and Radiosensitivity after administration of Pentxifyline."Proceedings of the Korean Association for Radiation Protection Autumn Meeting. Tague, Korea. October. 83-86 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YeunHwa Gu, Takeo Hasegawa, Tomoko Kusama: "The hyperthermia effects at organogenesis of ICR mouse on malformation and embryonic death."Research Reports of Suzuka University of Medical Science.. No.5. 60-68 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takumi Santokuya, YeunHwa Gu, Ikukatsu Suzuki, Takeo Hasegawa et al: "The radiation protection effects of TMG to the embryonic effects on the organogenesis stage in ICR mice."Proceedings of the Korea Association for Radiation Protection Autumn Meeting. Tague, Korea. October. 23-27 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YeunHwa Gu, Takeo Hasegawa, Takahiko Mori et al: "Combined Effects of Ionizing Radiation and Ultrasound on Malformation in ICR Mice at Organogenesis stage."J.Korean Association for Radiation Protection.. Vol. 24 No.1. 149-157(23-30) (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YeunHwa Gu, Takeo Hasegawa, Takehiko Mori et al: "Single and combined effects of Radiation and MRI on differential counts of leukocytes in ICR mice."Research Reports of Suzuka University of Medical Science.. No.6. 32-45 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YeunHwa Gu, Takeo Hasegawa, Ihlbohng Choi et al: "The combined effect of Radiation and MRI on Erythrocyte Leukocyte ant Thrombocyte of ICR mice,"Research Reports of Suzuka University of Medical Science.. No.6. 15-31 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeo Hasegawa, YeunHwa Gu, Tohru Takahashi et al: "Enhancement of Huperthermic Effects Using Rapid Heating Thermotherapy : Principles and Practice.-Applications in Neoplasia, Inflammation and Pain-"Edited by Kosaka M, Sugahara T, Schmidt K.L.,and Smion E., Springer-Verlag Tokyo, Inc.. (in press) (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeo Hasegaw, YeunHwa Gu, Chang W.Song et al: "Effects of Hyperthermia Induced Changes in pH Value on Tumor Response and Thermotolerance. Thermotherapy : Principles and Practice.-Applications in Neoplasia, Inflummation and Pain-"Edited by Kosaka M, Sugahara T, Schmidt., K.L. and Simon E..Springer-Verlag Tokyo, Inc.. (in press) (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ihlbong Choi,Yeunhwa Gu,Takeo Hasegawa et al.: "Malformation and Embryonic Death in ICR Mice after Mild Hyperthemia"日本ハイパーサミア学会誌. 14(4). 235-243 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takeo Hasegawa,Yeun hwa Gu,Tohru Takahashi,et al.: "Influence of an Anesthetic(Pentobarbital)on Hyperthermic Effects."Rwsearch Reports of Suzuka University of Medical Science.. No.5. 91-99 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takeo Hasegawa,Yeun hwa Gu,Ikukatsu Suzuki et al.: "Increase of the blood flow in the tissues by direct current magnetic field."Rwsearch Reports of Suzuka University of Medical Science.. No.5. 163-168 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takeo Hasegawa,Toshiaki Nishiguchi,Yeun hwa Gu et al.: "Increases in Blood Flow in Specific Organs after Stimulation of Pressure Point in the Soles."Rwsearch Reports of Suzuka University of Medical Science.. No.5. 169-175 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takeo Hasegawa,Yeun hwa Gu,Hiroaki Ushiba et al.: "Non-invasive temperature monitoring using small coils during radio-frequency heating."Proceeding of the Korean Association for Radiation Protection Autumn Meetiog.(Tague,Korea,Oct,22,1999). Vol.1. 49-52 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takeo Hasegawa,Yeun hwa Gu,Takashi Hasegawa et al.: "Potentiation of Hyperthermic Effects Using Vasodilator(Hydralazine)."Proceeding of the Korean Association for Radiation Protection Autumn Meetiog.(Tague,Korea,Oct,22,1999). Vol.1. 79-82 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 長谷川武夫、具 然和、山本五郎: "難治癌への挑戦 ハイパーサーミアの臨床(編集:松田忠義、菅原 努、阿部光幸)"株式会社医療科学社. 445 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 長谷川武夫: "麻酔剤(ペントバルビタール)の温熱効果に対する影響" 鈴鹿医療科学大学紀要. No.5. P92-P100 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 長谷川武夫: "静磁場による組織血流の上昇" 鈴鹿医療科学大学紀要. No.5. P163-P168 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 長谷川武夫: "足裏のツボ刺激による特定臓器の血流増加(サーモグラフィー温度画像による体表温度の確認)" 鈴鹿医療科学大学紀要. No.5. P169-P175 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 具 然和: "ICRマウスの器官形成期において温熱が及ぼす奇形及び胚死亡への影響" 鈴鹿医療科学大学紀要. No.5. P60-P68 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ihibong CHOI: "Malformation and Embryonic Death in ICR Mice after Mild Hyperthermia." Japanese journal of Hyperthermic Oncology. 14・4. P235-P243 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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