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Tumor suppressor gene predict response to chemoembolization therapy in advanced cervical cancer

Research Project

Project/Area Number 10670878
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKANSAI MEDICAL UNIVERSITY

Principal Investigator

HARIMA Keizoo  Kansai Med. Univ. Radiology, Associate Professor, 医学部, 助教授 (20121973)

Co-Investigator(Kenkyū-buntansha) HARIMA Yoko  Kansai Med. Univ. Radiology, Assistant Professor, 医学部, 講師 (80140276)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1999: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1998: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsCervical carcinoma / Transcatheter arterial chemoembolization / Tumor suppressor gene / Predictive marker
Research Abstract

Purpose : The ratio of Bcl-2 to Bax expression determines survival or death following an apoptotic stimulus. In order to establish a new predictor of the outcome of treatment for human cervical carcinoma, we investigated the relationship between the expressions of the Bax and Bcl-2 proteins and the response to chemoembolization using CDDP comparing pre- and after treatment.
Methods : A total of 40 patients with histologically proven carcinoma of the uterine cervix, including three with recurrent cervical stump carcinomas, were treated with definitive chemoembolization using CDDP. The presence of mutations in exons 5-8 of the p53 gene was analyzed by a single-strand conformation polymorphism analysis and DNA sequencing.
Results : Thirty six patients were found to have wild-type p53, and the remaining four had mutant p53. P53 gene did not correlated with the response to chemoembolization and survival. The Bax and Bcl-2 protein expressions prior to chemoembolization did not correlate with response or survival.
However, the Bax and Bcl-2 protein expressions after chemoembolization correlated with both response or survival. Bax-positive tumors showed significantly better responses than the Bax-negative tumors after chemoembolization (P=0.02). In contrast, the Bcl-2-positive tumors showed significantly poorer responses than the Bcl-2-negative tumors after chemoembolization (P=0.02). Increased Bax expression after chemoembolization was found to be correlated with good survival (P=0.04). In contrast, increased Bcl-2 expression after such chemoembolization was correlated with poor survival (P=0.002).
Conclusion : The levels of Bax and Bcl-2 expression after chemoembolization are useful prognostic markers in patients with human cervical carcinoma.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Yoko Harima: "Bax and Bcl-2 expression predict response to radiotherapy in human cervical cancer"J Cancer Res Clin Oncol. 124. 503-510 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoko Harima: "Genetic alterations on chromosome 17p associated with response to radiotherapy in bulky cervical cancer"Br J Cancer. 81. 108-113 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoko Harima: "Bax and Bcl-2 protein expression following radiation therapy versus radiation plus thermoradiotherapy in Stage IIIb cervical carcinoma"Cancer. 88. 131-137 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoko Harima: "Loss of heterozygosity on chromosome 6p21.2 as a potential marker for recurrence after radiotherapy of human cervical cancer"Clin Cancer Res. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Atsutoshi Oka: "Determination of p53-mediated transactivational ability in radiation-treated cervical cancer"Cancer Detect Prev. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 播磨洋子: "子宮頸癌の遺伝子異常の臨床における意義"放射線生物研究. 34. 1-9 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 播磨洋子: "ハイパーサーミアの臨床 遺伝子異常とハイパーサーミアの効果"松田忠義、菅原 努、阿部光幸、田中敬正 編集 医療科学社. 445 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 播磨洋子: "癌の放射線治療 放射線感受性予測法"田中敬正、平岡眞寛、赤木清 笹井啓資 編集 金芳堂. 234 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoko Harima, Kenji Nagata, Keizo Harima, Atsutoshi Oka, Valentina V. Ostapenko, Nobuaki Shikata, Takeo Ohnishi, Yoshimasa Tanaka: "Bax and Bcl-2 protein expression following radiation therapy versus radiation plus thermoradiotherapy in Stage IIIb cervical carcinoma."Cancer. 81-1. 131-137 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoko Harima, Keizo Harima, Satoshi Sawada, Yoshimasa Tanaka, Seizaburo Arita, Takeo Ohnishi.: "Loss of heterozygosity on chromosome 6p21.2 as a petential marker for recurrence after radiotherapy of human cervical cancer."Clin Cancer Res.. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Atsushi Oka, Yoko Harima, Keizo Harima, Valentina V. Ostapenko, Yoshimasa Tanaka, Takeo Ohnihsi, Satoshi Sawada: "Determination of p53-mediated transactivational ability in radiation-treated cervical cencer."Cancer Detct Prev.. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoko Harima, Syuya Shirahama, Keizo Harima, Satomi Aoki, Takeo Ohnishi, Yoshimasa Tanaka: "Genetic alterations on chromosome 17p associated with response to radiotherapy in bulky cervical cancer."Brit J Cancer. 81-1. 108-113 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoko Harima, Keizo Harima, Nobuaki Shikata, Atsutoshi Oka, Takeo Ohnishi, Yoshimasa Tanaka: "Bax and Bcl-2 expression predict response to radiotherapy in human cervical cancer."J Cancer Res Clin Oncol. 124. 503-510 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoko Harima, Atsutoshi Oka, Keizo Harima, Yoshimasa Tanaka: "WAS1 induction and infection by HPV E6 as a determinants of radiosensitivity in human cervical cancer."Jpn, J, Cancer Clin.. 44. 185-186 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y. Harima, Atsutoshi Oka, Kenji Nagata, keizo Harima, Yoshimasa Tanaka, Nobuaki Shikata: "Bax and Bcl-2 expression predict response to radiotherapy in human cervical cancer"Jpn. J. Cancer Chemother.. 25. 1273-1277 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoko Harima: "Bax and Bcl-2 expression predict response to radiotherapy in human cervical cancer"J Cancer Res Clin Oncol. 124. 503-510 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yoko Harima: "Genetic alterations on chromosome 17p associated with response to radiotherapy in bulky cervical cancer"Br J Cancer. 81(1). 108-113 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yoko Harima: "Bax and Bcl-2 protein expression following radiation therapy versus radiation plus thermoradiotherapy in Stage IIIb cervical carcinoma"Cancer. 88(1). 131-137 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yoko Harima: "Loss of heterozygosity on chromosome 6p21.2 as a potential marker for recurrence after radiotherapy of human cervical cancer"Clin Cancer Res. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Atsutoshi Oka: "Determination of p53-mediated transactivational ability in radiation-treated cervical cancer"Cancer Detect Prev. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Isoda H: "Squamous cell carcinoma arising in a mature teratoma with metastasis to the urinary bladder"Comput Med Imaging Graph. 23(4). 223-225 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 播磨洋子: "ハイパーサーミアの臨床 遺伝子異常とハイパーサーミアの効果"松田忠義、菅原 努、阿部光幸、田中敬正、編集 医療科学社. 445 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 播磨洋子: "癌の放射線治療 放射線感受性予測法"田中敬正、平岡眞寛、赤木清、笹井啓資 編集 金芳堂. 234 (1998)

    • Related Report
      1999 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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