| Project/Area Number |
10670882
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tokyo Metropolitan Institute of Gerontology |
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Principal Investigator |
SENDA Michio Tokyo Metropolitan Institute of Gerontology, Positron Medical Center, Head, ポジトロン医学研究部門, 研究室長 (00216558)
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| Co-Investigator(Kenkyū-buntansha) |
SADATO Norihiro National Institute for Physiological Sciences, Psychophysiology Section Department of Cerebral Research, Professor, 大脳皮質機能心理生理, 教授 (00273003)
ODA Keiichi Tokyo Metropolitan Institute of Gerontology, Positron Medical Center, Assistant Researcher, ポジトロン医学研究部門, 研究助手 (70224235)
ISHII Kenji Tokyo Metropolitan Institute of Gerontology, Positron Medical Center, Assistant Researcher, ポジトロン医学研究部門, 研究助手 (10231135)
KANNO Iwao Akita Research Institute of Brain and Blood Vessels, Department of Radiology and Nuclear medicine, Vice Director of Research Bureau, 副研究局長
FUKUDA Hiroshi Tohoku University, Institute of Development, Aging and Cancer, Professor, 加齢医学研究所, 教授 (30125645)
外山 比南子 財団法人 東京都老人総合研究所, ポジトロン医学研究部門, 主任研究員 (50180188)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1999: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1998: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | PET / FDG / Regional cerebral glucose metabolism / input function / kinetic model / anatomical standardization / SPM |
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| Research Abstract |
Positron emission tomography (PET) with F-18 labeled fluorodeoxyglucose (FDG) provides noninvasive imaging of glucose metabolism of the human brain and is useful for diagnosis of Alzheimer's disease, epilepsy and other neurological disorders. However, it is not easy to collect a sufficient number of normal data in each PET center, and the data acquired in other centers may not be used. Five PET centers participated in this research project to create a normal database to facilitate standardization of FDG-PET measurement. Data were transformed into Dr. View or Analyze format. When the time course of FDG arterial concentration was normalized by the injected dose per body surface area, which had been described optimally with height and body weight, the integral of the input function resulted in an individual variation of 7%. Between-center difference was not observed in the standardized input function. Allowing for the noise, the regional cerebral FDG uptake measured 45-60 minutes post injection divided by the integrated input was almost, though not exactly, equal to the influx rate constant of FDG estimated with a kinetic analysis, and provided a good estimate of the rate of glucose metabolism. Combined with standardization of the input function, this suggested a possibility of estimating the cerebral metabolic rate of glucose from a single-frame PET image without arterial sampling. When the FDG images of elderly subjects were spatially normalized with SPM, the flexion-extension angle was erroneously determined in some cases. When the FDG images were spatially normalized with SPM using the CBF template image, the occipital lobe was distorted and pushed downward into the cerebellum, suggesting the necessity of using an FDG template image for spatial normalization.
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