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Analysis of Semantic and Working Memory in Schizophrenia by Event-Related Potentials

Research Project

Project/Area Number 10670885
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

MATSUOKA Hiroo  Psychiatry, Graduate School of Medicine, Tohoku University, Associate Professor, 大学院・医学系研究科, 助教授 (00173815)

Co-Investigator(Kenkyū-buntansha) YAMAZAKI Hisato  Psychiatry, University Hospitals, Research Associate, 医学部・附属病院, 助手 (30271951)
SATO Mitsumoto  Psychiatry, Graduate School of Medicine, Tohoku University, Professor, 大学院・医学系研究科, 教授 (70033321)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
KeywordsEvent-related potential / Schizophrenia / Semantic memory / Working memory / Repetition priming / Thought disorder / N400 / 視覚性事象関連電位 / NA
Research Abstract

We have examined a pathophysiology of schizophrenia observed in the domains of cognitive functions such as perception, thinking (language), and memory by using a new experimental paradigm in visual event-related brain potential study, and found aberrant NA and N400 potentials in remitted patients, which reflect a pattern-recognition and a semantic processing, respectively. Our prospective follow-up study confirmed the NA abnormality to be a vulnerability marker of psychotic relapse characterized by florid hallucination and delusion. This study was designed to investigate a pathogenesis of N400 abnormality in schizophrenia and its clinical significance with a special reference to schizophrenic thought disturbance assessed by Thought Disorder Index (TDI) (Johnston and Holzman 1979).
Parameters of N400 did not correlate to those of NA, and N400 abnormality was clearly observed in repetition priming rather than semantic processing of Japanese words. Repetition priming f N400 did not correlate to the total TDI scores. Then we divided into low TDI and high TDI patients according to TDI scores, and found a robust correlation between repetition priming and thought disturbance only in high TDI patients. These results suggest that aberrant N400 may be independent of NA abnormality, that aberrant N400 may not be due to a deficit in N400 generation mechanism (semantic processing) but a deficit in N400 regulation mechanism (memory processing), and that a part of schizophrenic thought disturbance may be caused by a deficit in working memory.
Recent studies have reported that schizophrenic symptoms consist f three dimensions ; psychotic symptoms (hallucination and delusion), formal thought disorder, and deficit symptoms. In addition to such a clinical heterogeneity in schizophrenia, our data suggest a heterogeneity in a level of pathophysiology because aberrant NA as a vulnerability of psychotic symptoms was independent of aberrant N400 as and index of thought disturbance.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] 松岡洋夫: "精神分裂病の脆弱性概念"脳と精神の医学. 10・2. 111-120 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroo Matsuoka et al.: "Delayed visual NA potential in remitted schigohorenia"Biological Psychiatry. 45・1. 107-115 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroo Matsuoka et al.: "Lack of repetition priming effect on visual event-related potentials in schizophrenia"Biological Psychiatry. 46・1. 137-140 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 西尾雅明 他: "精神分裂病の外来維持療法"精神科治療学. (印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松岡洋夫: "精神分裂病治療のヒントを与える病態生理仮説"こころの科学. (印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 佐藤光源 他: "臨床精神医学講座第2巻精神分裂病I"中山書店. 471 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 戸田重誠: "精神医学レビューNo.33精神障害における心因"ライフ・サイエンス. 121 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroo Matsuoka: "Concept of Vulnerability in schizophrenia"Brain Science and Mental Disorders. 10(2). 111-120 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroo Matsuoka et al.: "Delayed visual NA potential in remitted Schizphrenia"Biological Psychiatry. 45(1). 107-115 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroo Matsuoka et al.: "Lack of repetition priming effect on visual event-related potentials in schizophrenia"Biological Psychiatry. 46(1). 137-140 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masaaki Nishio et al.: "Maintenance therapy for outpatients with Schizophrenia"Jpn Journal of Psychiatric Treatment. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroo Matsuoka: "Pathophysiological hypothesis useful for treatment of schizophrenia"Human Mind. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mitsumoto Sato et al.: "Encyclopedia of Clinical Psychiatry (Schizophrenia I)"Edited by Noboru Nakane, Tsukasa, Koyama, Shinichi Niwa, Nobuo Nakayasu (Nakayama Shoten). 471 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shigeaki Toda et al.: "Review in Psychiatry"Edited by Tohru Takahashi (Life-Science). 121 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松岡洋夫: "精神分裂病の脆弱性概念"脳と精神の医学. 10・2. 111-120 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hiroo Matsuoka et al.: "Delayed visual NA potential in remitted schizophrenia"Biological Psychiatry. 45・1. 107-115 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hiroo Matsuoka et al.: "Lack of repetition priming effect on visual event-related potentials in schizophrenia"Biological Psychiatry. 46・1. 137-140 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 西尾雅明 他: "精神分裂病の外来維持療法"精神化治療学. (印刷中). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松岡洋夫: "分裂病治療のヒントを与える病態生理仮説"こころの科学. (印刷中). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 佐藤光源 他: "臨床精神医学講座 第2巻 精神分裂病I"中山書店. 471 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 戸田重誠 他: "精神医学レビュー NO.33 精神障害における心因"ライフ・サイエンス. 121 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松岡洋夫 他: "精神疾患における認知機能障害" 臨床精神薬理. 1・11. 1099-1110 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 松岡洋夫 他: "分裂病の意味処理障害-最近のN400研究" 脳と精神の医学. 9・3. 287-294 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hiroo Matsuoka et al.: "Delayed visual NA potential in remitted schizophrenia" Biol.Phychiathy. 45・1. 107-115 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 松岡洋夫: "精神分裂病の脆弱性概念" 脳と精神の医学. (印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hiroo Matsuoka et al.: "Lack of repetition priming effect on visual event-related potentials in schizonhrenia" Biol.Psychiatry. in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 松岡洋夫 他: "精神医学レビューNo.27(精神疾患の認知障害)" 丹羽真一 編集(ライフ・サイエンス社), 189 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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