| Project/Area Number |
10670892
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Yamanashi Medical University |
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Principal Investigator |
SHIOE Kunihiko Yamanashi Medical University, Faculty of Medicine, assistant Professor, 医学部, 講師 (90215939)
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| Co-Investigator(Kenkyū-buntansha) |
HIRANO Masami Yamanashi Medical University, Faculty of Medicine, assistant Professor, 医学部, 講師 (80228808)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2000: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1999: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1998: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | dimensional classification of personality / behavioral genetics / polymorphism / serotonin transporter / dopamine receptor / mood disorder / ドーパミン受容体 / 病前性格 / ドーパミンD4受容体 / 分子遺伝学 / 人格傾向 |
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| Research Abstract |
We conducted visual investigations. On the D4DR gene, we classified homozygotes with 4 repeats/4 repeats as the M group, heterozygotes with 4 repeats/less than 4 repeats as the S group, and 4 repeats/more than 4 repeats as the L group. Next, we examined scores for distribution of TCI (NS, HA, RD, PS), and compared TCI.scores among the three groups. All 4 matrices were examined, but significant relationships were observed only between D4DR polymorphism and RD scores.
Afterwards, , we have penformed an association study of polymorphisms related to the promorter region of the serotonin transporter gene between patients with mood disorders and healthy subjects. Short allele frequency of bipolar patients was higher than controls.
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