| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1998: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Research Abstract |
1.Positive transfer effect of amygdaloi kindling was observed in various aged rats 15-, 18-, 28-, 4-day- as well as 70-day old rats. The acquired secondary epileptogenesis when initial kindling was induced in rats aged 40-postanal days, persisted after maturation. However, the secondary epileptogenesis when initial kindling was 15-, 18-, and 28- postnatal days, regressed during development.
These results suggested that the secondary epileptogenesis acquired during the immature stage regresses during maturation.
2.The number of stimulations required to reach the first stage 5 seizure during rekindling was significantly fewer and the afterdischarge durations during rekindling were significantly shorter than those in the control rats only in stage 4 or 5 suspended group.
These results suggested that the epileptogenesis acquired at the partial kindling stage is different to that acquired at the secondarily generalized stage and it regressed during the process of kindling development.
3.In the amygdaloid kindled rats, basal amino acids levels, such as aspartate, glutamate, GABA, released from the hippocampal synaptosomes were lower than those in the control. In addition, depolarization induced GABA release was lower compared to that in control rats.
These results suggested that kindling cause inhibition of inhibitory amino acids system in the hippocampus.
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