| Project/Area Number |
10670909
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
HIGA Tsukasa (1999) University Hospital, University of the Ryukyus, Instructor, 医学部・附属病院, 助手 (90284984)
兼島 瑞枝 (1998) 琉球大学, 医学部・附属病院, 助手 (20253958)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAMINE Masaru Genetic research center, University of the Ryukyus, Assistant Professor, 遺伝子実験施設, 助教授 (20189161)
比嘉 司 琉球大学, 医学部・附属病院, 助手 (90284984)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1999: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1998: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | An association study / Schizophrenia / Chromozome 6p / Spinocerebellar ataxia type 1 / Genetics / SCAI遺伝子 |
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| Research Abstract |
The gene for spinocerebellar ataxia type 1 (SCA1) is a potential candidate gene for schizophrenia because of previous positive linkage findings in this resion (6p22-24), and the reported correlation between SCA1 onset and the number of CAG repeats suggesting anticipation. To evaluate whether the SCA1 gene might be involved in susceptibility to schizophrenia, we examined the amino-acid variant (S186C) of 83 Okinawan patients with schizophrenia and 104 Okinawan controls. This amino-acid change was not found in all of schizophrenia patients and controls. This result indicates that the amino-acid variant (S186C) is not relevant to schizophrenia.
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