| Project/Area Number |
10670911
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
NAKANO Norihito Sapporo Medical University, Neuropsychiatry, Assistant Prof., 医学部, 講師 (20284995)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Shinji Sapporo Medical University, Occupational Therapy, Professor, 保健医療学部, 教授 (30142756)
HAYASHI Yorihide Sapporo Medical University, Neuropsychiatry, Instructor, 医学部, 助手 (40315510)
SAITO Satoshi Sapporo Medical University, Neuropsychiatry, Instructor, 医学部, 助手 (30295357)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Alzheimer's disease / cerebral blood flow / eye movement / pathology / 画像 / 脳血流量 / 神経病理学 |
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| Research Abstract |
3) We have no autopsy case which have both quantitative rCBF data and neuropathological findings. Subsequently, we have a plan to examine both rCBF and neuropathological findings in autopsy cases.
We present comparative study between regional cerebral blood flow (rCBF) and eye movement, and neuropathology in AD. Additionally, we also present comparative study between alterations in quantitative rCBF and neuropathological findings (Aβ, NFT, neuronal count) in autopsy cases.
1) These AD and three healthy controls (HC) were examined eye-head coordination and rCBF, AD reduced gaze accuracy and head movements, and prolonged the latency of saccade as compared to HC, AD reduced rCBF in the inferior parietal part and visual area. Damage of these areas may have caused eye head coordination disorders in AD.
2) AGEs have been implicated in the chronic complication of DM and play an important role in the pathogenesis of AD. In most senile plaques, AGEs and ApoE were observed together. However, approximately 5% of plaques were AGE positive but Aβ negative. AGEs were mainly present in intracellular NFTs, whereas ApoE was mainly present in extracellular NFTs. In this study suggested that AGE may contribute to eventual neuronal dysfunction and death as an important factor in AD.
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