| Project/Area Number |
10670912
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
FUKUI Kenji Kyoto Prefectural University of Medicine, Psychiatry, Professor, 医学部, 教授 (50165263)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1999: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | organic solvent / abuse / neurotoxicity / amotivational syndrome / hippocampus / rat / functional morphology / 形態学 / 有機溶剤乱用 / 動固喪失症候群 / ラット脳 / 電子顕微鏡 |
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| Research Abstract |
Using chronic toluene-treated rats as the model of amotivational syndrome in humans, I tried to elucidate the mechanism of the syndrome from the point of morphological approach. Hippocampus that is closely related with emotion and memory was observed by light and electron microscopy after the toluene inhalation.
(1)The number of the degenerative granular cell in the hippocampus were counted. The number in the chronic toluene-treated (22.5%) was significantly higher than that of control rat (8.2%).
(2)After the inhalation of toluene (3 months), vasoactive and metabolic activating drug was treated for 1 month. Memory function was tested by the passive avoidant behavior method. The retention time in the light room of vasoactive metabolic activating drug-treated rat was longer (155.45±27.36sec) than that of non-treated rat (90.59±10.43sec) significantly.
Chronic toluene treatment caused the degeneration in the granular cells in the dentate gyrus of the hippocampus and the treatment of vasoactive metabolic activating drug might improve the degeneration induced by toluene inhalation.
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