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Morphological research on amotivational syndrome induced by organic solvent inhalation -its mechanism and treatment-

Research Project

Project/Area Number 10670912
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

FUKUI Kenji  Kyoto Prefectural University of Medicine, Psychiatry, Professor, 医学部, 教授 (50165263)

Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1999: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
Keywordsorganic solvent / abuse / neurotoxicity / amotivational syndrome / hippocampus / rat / functional morphology / 形態学 / 有機溶剤乱用 / 動固喪失症候群 / ラット脳 / 電子顕微鏡
Research Abstract

Using chronic toluene-treated rats as the model of amotivational syndrome in humans, I tried to elucidate the mechanism of the syndrome from the point of morphological approach. Hippocampus that is closely related with emotion and memory was observed by light and electron microscopy after the toluene inhalation.
(1)The number of the degenerative granular cell in the hippocampus were counted. The number in the chronic toluene-treated (22.5%) was significantly higher than that of control rat (8.2%).
(2)After the inhalation of toluene (3 months), vasoactive and metabolic activating drug was treated for 1 month. Memory function was tested by the passive avoidant behavior method. The retention time in the light room of vasoactive metabolic activating drug-treated rat was longer (155.45±27.36sec) than that of non-treated rat (90.59±10.43sec) significantly.
Chronic toluene treatment caused the degeneration in the granular cells in the dentate gyrus of the hippocampus and the treatment of vasoactive metabolic activating drug might improve the degeneration induced by toluene inhalation.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] 北林 百合之介 他: "有機溶剤の乱用と依存"医学のあゆみ. 193. 692 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 北林 百合之介 他: "動因喪失症候群を呈した有機溶剤乱用の一例"日本アルコール・薬物医学会雑誌. 34. 130-137 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 小林 豊生 他: "慢性有機溶剤乱用に関する神経心理学的研究"日本アルコール・薬物医学会雑誌. 34. 278-279 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 宮田 久嗣 他: "ニコチン・アルコール・覚醒剤,有機溶剤,抗不安・睡眠薬依存の臨床像の比較に関する研究"日本神経精神薬理学雑誌. 20. 233-236 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 福居 顯二 他: "臨床精神医学講座 第8巻 薬物・アルコール関連障害"中山書店. 436 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kitabayashi, Y. et al.: "Organic solvent abuse and dependence."Igaku no Ayumi. 193. 692 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kitabayashi, Y. et al.: "A case report of organic solvent abuse with amotivational syndrome."Japanese Journal of Alcohol Studies and Drug Dependence. 34. 130-137 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kobayashi, T. et al.: "Neuropsychological study on chronic organic solvent abuse."Japanese Journal of Alcohol Studies and Drug Dependence. 34. 278-279 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Miyata, H. et al.: "Clinical comparative study on the features of nicotine, alcohol, methamphetamine, organic solvent and antianxiety drug hypnotics"Japanese Journal of Neuropsychopharmacology. 20. 233-236 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary

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Published: 1998-04-01   Modified: 2016-04-21  

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