| Project/Area Number |
10670913
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | NARA MEDICAL UNIVERSITY |
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Principal Investigator |
KISHIMOTO Toshifumi Nara Medical University, Departments of Psychiatry, Professor, 医学部, 教授 (60201456)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1999: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1998: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | water-intake / arginine vasopressin / supraoptic nucleus / haloperidol / SIADH / 抗精神病薬 / バソプレッシン / マイクロダイアリシス法 / モノアミン |
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| Research Abstract |
Water intoxication in Schizoprenic patient is characterized by morbid polydipsia and induces severe symptoms such as conscious disturbance and convulsions. And treatment with antipsychotics has been speculated as one of the causal factors in this disorder. Although several mechanisms responsible for development of water intoxication have been proposed, they are still unclear. In this study, we have undertaken to investigate the effect of chronic treatment (8 weeks) with haloperidol decanoate(HalomonthR ; 10, 20 mg/kg, i.m.) on arginine vasopressin (AVP) release and behavioral changes (water-intake and ambulation) by hyperosmotic stimulation of the supraoptic nucleus (SON) in rats.
1) The incidence of water-intake mainly produced 30-60 min (third period) after hyperosmotic stimulation. In particular, there was a marked increase in the incidence and volume of water-intake in haloperidol treated animals.
2) AVP levels were increased 30-90 min after hyperosmotic stimulation in the same animals.
3) Dopamine levels in striatum in haloperidol treated animals were smaller than those in the control.
We demonstrated that chronic treatment with haloperidol decanoate enhanced hyperosmotic stimulation-induced water-intake and release of AVP in SON. These results suggest that the increasing effect of water-intake and AVP levels caused by chronic haloperidol treatment may connect with interaction between AVP and dopaminergic system in SON.
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