• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A study on brain function and morphology changes in psychoses of epilepsy

Research Project

Project/Area Number 10670920
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionNihon University School of Medicine

Principal Investigator

MATSUURA Masato  Nihon University School of Medicine, Associate Professor, 医学部, 助授 (60134673)

Co-Investigator(Kenkyū-buntansha) SAKAI Teiichiro  Nihon University School of Medicine, Assistant, 医学部, 助手 (80225763)
KOJIMA Takuya  Nihon University School of Medicine, Professor, 医学部, 教授 (40014203)
高橋 栄  日本大学, 医学部, 助手 (70297802)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordsepileptic psychosis / heterogeneity / multi-axial diagnosis / temporal lobe epilepsy / forced normalization / focus laterality / hippocampal atrophy / multi-factor etioloty / 多軸分類 / てんかん類型 / 精神病類型 / 発作・脳波関連 / 発病背景 / 器質的背景
Research Abstract

We developed a new five-axial diagnostic scheme for epileptic psychoses, which describes all clinical information systematically. Using this scheme, we conducted a multi-center study and 128 cases (63 males and 65 females) with epileptic psychoses were recruited from five institutions. The average age was 39.9±12.8 years, that of epilepsy onset was 13.5±9.8 years, and that of psychoses onset was 27.9±9.5 years. Types of psychoses, coded at the axis 1, were heterogeneous as follows; paranoid schizophrenia-like psychosis, chronic delusional disorder, acute transient psychotic disorder, hebephrenic schizophrenia-like psychosis, catatonic disorder, hallucinosis, in order. No changes in EEG at the onset of psychosis, coded at the axis 3, were proven in most of cases, and only eight cases showed normalization and only four showed aggravation in their EEG. No side-preferences in epileptic focus were proven. As many as 49 cases, coded at the axis 5, showed various abnormalities by brain imagin … More g examinations, such as diffuse brain atrophy, unilateral hippocampal atrophy, focal brain atrophy, tumorous lesions, cortical dysplasia, in order. Thirty-four cases had a previous history of brain damages, such as encephalitis, birth trauma, contusion, infantile status epilepticus, post-operative state of brain tumor, cerebro-vascular disorders, in order. Intelligent disturbances were prevalent, 38 with mild disturbance and 12 with moderate disturbances. These patients with epileptic psychoses were compared with 53 patients with functional psychoses who were matched in age, sex, and age at the onset of psychoses using operational polydiagnostic criteria (OPCRIT) developed by McGuffin in 1998. The inter-rater accordance was over 90% in 29 symptoms, over 80% in 26 symptoms, over 70% in 18 symptoms, and over 60% in four symptoms. Compared with functional psychoses, epileptic psychoses showed less Schneider's first rank symptoms, systematic delusions, auditory hallucinations persist more than a week, persecutory delusions, slowness in activity, poor thought contents, and affective flattening, and showed more ununderstandable conversation and inappropriate affect. The DSM-IV diagnosis showed that unspecified psychotic disorder was prevalent in epileptic psychoses, especially in temporal lobe epilepsy and in post-ictal psychosis Epileptic psychoses were thought to be a different clinical entity from functional psychoses. Because of a wide heterogeneity of epileptic psychoses, the present multi-axial diagnosis is thought to be useful to identify their etiology. Less

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (68 results)

All Other

All Publications (68 results)

  • [Publications] 松浦雅人: "見逃されやすい側頭葉てんかん"精神科治療学. 13/2. 245-250 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松浦雅人: "てんかん性精神病の診断と分類"精神科診断学. 9/4. 533-542 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松浦雅人: "成人てんかんの診断の進歩"ともしび. 2. 7-8 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松浦雅人: "てんかん最前線、抗てんかん薬と精神症状、薬は精神症状を悪化させうるか"波. 22/7. 228-231 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuura M: "Epileptic psychoses and anticonvulsant drug treatment"J Neurol Neurosurg Psychiatry. 67/2. 231-233 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松浦雅人: "てんかんを合併したparoxysmal kinesigenic choreoathetosisの1家系"精神科治療学. 14/5. 573-578 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松浦雅人: "Lennox-Gastaut症候群の成人例"精神科治療学. 14(4). 1031-1036 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松浦雅人: "てんかんの一次予防"精神医学レビュー. 30. 79-86 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松浦雅人: "思春期のてんかん児の抱える問題-精神科医の立場から"波. 5. 147-148 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuura M: "Indication of surgery for epilepsy patients with psychopathology"Epilepsia. (印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuura M: "Patients satisfaction with polypharmacy reduction in chronic epileptics"Psychiatry Clin Neurosci. (印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松浦雅人: "欠神発作重積状態を繰り返した成人例"精神科治療学. 15(1). 119-124 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松浦雅人: "てんかん精神病の多軸診断"神経進歩. 44・1. 92-102 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松浦雅人(分担執筆): "てんかん"医学書院(日野原重明、阿部正和監修:今日の治療指針1998年版). 262-264 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松浦雅人(分担執筆): "抗てんかん薬投与中の幻覚妄想状態"診療新社(八木剛平編:新精神科選書4). 256-264 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松浦雅人(分担執筆): "てんかんと精神症状、持続性精神症状"中山書店(松下正明編:臨床精神医学講座9). 422-434 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松浦雅人(分担執筆): "てんかん"文光堂(矢崎義雄、和田攻、大久保昭行、永田直一:新内科治療ガイド). 366-374 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] "てんかん、ナルコレプシー、クライネ・レビン症候群"中山書店(織田敏次、森亘総監督:ハイパー臨床内科)(CD-ROM). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] "偽発作の診断と治療"小島卓也編:てんかんの診断と治療(印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuura M et al.: "Undetected temporal lobe epilepsy."Jpn J Psychiatra Ther. 13 (2). 245-250 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuura M: "Diagnosis and classification of epileptic psychoses."Jpn J Psychiatr Diag. 9 (4). 533-542 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuura M: "Progress in diagnosis of adult epelepsy."Tomoshibi. 2. 7-8 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuura M.: "Do antiepileptics aggravate psychopathology in epilepsy?"Nami. 22 (7). 228-231 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuura M: "Epilepsy, In: Current Therapeutic Guideline 1998."Igaku-shoin. 262-264 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuura M: "Paranoid-hallucionatory state during antiepileptic drug treatment. In: New Selection in Psychiatry 4."Seiwa-shoten. 256-264 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuura M: "Perisistent psychopathology in epilepsy. In: Handbook of Clinical Psychiatry 9."Nakayama-shoten. 422-434 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuura M: "Epileptic psychoses and antiepileptic drug treatment."J Neurol Neurosurg Psychiatry. 67 (2). 231-233 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuura M: "Familial cases with epilepsy and paroxysmal kinesigenic choreoathetosis."Jpn H Psychiatr Ther. 14 (5). 573-578 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuura M et al.: "Adult cases of Lennox-Gastaut syndrome."Jpn J Psychiatr Ther. 14 (9). 1031-1036 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuura M: "Primary prevention of epilepsy."Rev Psychiatry. 30. 79-86 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuura M: "Psychiatric problems in adolescent epileptics."Nami. 5. 147-148 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuura M: "Epilepsy. In: New Therapy Guides in Internal Medicine."Bunkodo. 1999. 374 (366)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuura M: "Epilepsy, narcolepsy, Kleine-Levin syndrome. In: Hyper Clinical Internal Medicine."Nakayama-shoten. CD-ROM Ver 2. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuura M et al.: "An adult case with repeated absence status epileptics."Jpn J Psychiater Ther. 15 (1). 119-124 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuura M et al.: "Multi-axis diagnosis of epilepsy."Adv Neurology. 44 (1). 92-102 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuura M: "Patients satisfaction with polyphrmacy reduction. In chronic epileptics."Psychiatry Clin Neurosci (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuura M: "Indication of surgery for epilepsy patients with psychopathology."Epilepsia. (in pres). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuura M: "Diagnosis and treatment of pseudoseizures. In: Diagnosis and Treatment of Epilepsy"Shinko-Koi Med Publ. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松浦雅人: "見逃されやすい側頭葉てんかん"精神科治療学. 13/2. 245-250 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松浦雅人: "てんかん性精神病の診断と分類"精神科診断学. 9/4. 533-542 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松浦雅人: "成人てんかんの診断の進歩"ともしび. 2. 7-8 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松浦雅人: "てんかん最前線,抗てんかん薬と精神症状,薬は精神症状を悪化させうるか"波. 22/7. 228-231 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Matsuura M: "Epileptic psychoses and anticonvulsant drug treatment"J Neurol Neurosurg Psychiatry. 67/2. 231-233 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松浦雅人: "てんかんを合併したparoxysmal kinesigenic choreoathetosisの1家系"精神科治療学. 14/5. 573-578 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松浦雅人: "Lennox-Gastaut症候群の成人例"精神科治療学. 14. 1031-1036 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松浦雅人: "てんかんの一次予防"精神医学レビュー. 30. 79-86 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松浦雅人: "思春期のてんかん児の抱える問題-精神科医の立場から"波. 5. 147-148 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Matsuura M: "Indication of surgery for epilepsy patients with psychopathology"Epilepsia. (印刷中). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Matsuura M: "Patients satisfaction with polypharmacy reduction in chronic epileptics"Psychiatry Clin Neurosci. (印刷中). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松浦雅人: "欠神発作重積状態を繰り返した成人例"精神科治療学. 15.1. 119-124 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松浦雅人: "てんかん精神病の多軸診断"神経進歩. 44.1. 92-102 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松浦雅人(分担執筆): "てんかん"医学書院(日野原重明,阿部正和監修:今日の治療指針1998年版). 3 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松浦雅人(分担執筆): "抗てんかん薬投与中の幻覚妄想状態"診療新社(八木剛平編:新精神科選書4). 9 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松浦雅人(分担執筆): "てんかんと精神症状,持続性精神症状"中山書店(松下正明編:臨床精神医学講座9). 13 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松浦雅人(分担執筆): "てんかん"文光道(矢崎義雄,和田攻,大久保昭行,永田直一編:新内科治療ガイド). 9 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] "てんかん.ナルコレプシー.クライネ・レビン症候群"中山書店(織田敏次、森亘総監修:ハイパー臨床内科). CD-ROM (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] "偽発作の診断と治療"小島卓也編:てんかんの診断と治療(印刷中). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松浦雅人他: "見逃されやすい側頭葉てんかん" 精神科治療学. 13・2. 245-250 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 松浦雅人: "光過敏畝性発作作について" 精神科治療学. 13・5. 649-655 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 松浦雅人他: "HHE症候群の脳波" 精神科治療学. 13・9. 1173-1177 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 松浦雅人: "てんかん精神病の診断と分類" 精神科診断学. 9・4. 533-542 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 松浦雅人: "成人てんかんの診断の進歩" ともしび. 2. 7-8 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 松浦雅人: "てんかん最前線 抗てんかん薬と精神症状" 波. 22・7. 228-231 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 久郷敏明他: "日本語版SEALSの多施設共同研究" てんかん研究. 16・1. 1-8 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 松浦雅人: "今日の治療指針1998年版「てんかん」" 医学書院, 1437 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Adachi N: "Is postictal psychosis a separate clinical entity?" Europian Congress of Epileptology, (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 松浦雅人: "臨床精神医学講座9 てんかん 持続性精神症状" 中山書店, (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 松浦雅人(監訳): "てんかんハンドブック" メディカル・サイエンス・インターナショナル, 223 (1998)

    • Related Report
      1998 Annual Research Report

URL: 

Published: 1998-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi