| Project/Area Number |
10670925
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Occupational and Environmental Health(UOEH) |
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Principal Investigator |
NAKAMURA Jun Dept.of Psychiatry, School of Medicine, UOEH, Professor, 医学部, 教授 (40148804)
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| Co-Investigator(Kenkyū-buntansha) |
OHMORI Osamu Dept.of Psychiatry, School of Medicine, UOEH, Assistant Professor, 医学部, 講師 (70248558)
YOSHIMURA Reiji Dept.of Psychiatry, School of Medicine, UOEH, Assistant Professor, 医学部, 講師 (90248568)
TERAO Takeshi Dept.of Psychiatry, School of Medicine, UOEH, Associate Professor, 医学部, 助教授 (80217413)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2000: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
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| Keywords | delirium / 3-methoxy-4-hydroxyphenylglycol(MHPG) / Natural killer(NK)cell activity / Prospective study |
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| Research Abstract |
We measured and comparaed levels of plasma free 3-methoxy-4-hydroxy-phenyl-(ethylene)glycol(pMHPG), a major metabolite of noradrenaline, and natural killer(NK)cell activity in 26 patients prior to undergoing operations for cardiovascular diseases 11 of whom expressed delirium and 15 of which did not. In conclusion, we found that pMHPG levels before the operations were higher in patients with post-operative delirium than in the patients without, while NK cell activity showed no difference between the two groups. It is possible that hyperactivity of noradrenargic neurons is connected with the development of post-operative delirium. Further, we considered that measurements of pMHPG level before operation might be a useful tool to predict the occurrence of post-operative delirium.
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