| Project/Area Number |
10670972
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|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | Tokyo Women's Medical University |
|---|
Principal Investigator |
MORI Naoki Tokyo Women's Medical Uniersity, Department of Hematology, Instructor, 医学部, 助手 (20241078)
|
|---|
| Project Period (FY) |
1998 – 1999
|
| Project Status |
Completed (Fiscal Year 1999)
|
| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1998: ¥900,000 (Direct Cost: ¥900,000)
|
|---|
| Keywords | CML / TUMOR SUPRESSOR GENE |
|---|
| Research Abstract |
Cytogenetic analysis showed no deletions of chromosome arm 1p in 70 patients with chronic myelocytic luekemia. Deletional mapping of 1p revealed that common region of loss of heterozygosity is proximal to D1S508 and distal to D1S507. RT-PCR analysis of the p73 gene was performed in 35 samples of CML. Expression of the gene was detected in most of the samples and gel electrophoresis showed no apparent abnormality of the cDNA products.
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