INTERLEUKIN (IL)-18 IN ACUTE GRAFT-VERSUS-HOST DISEASE
| Project/Area Number |
10670974
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | HYOGO COLLEGE OF MEDICINE |
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Principal Investigator |
FUJIMORI Yoshihiro HYOGO COLLEGE OF MEDICINE, DEPARTMENT OF MEDICINE, ASSISTANT PROFESSOR, 医学部, 助手 (20229058)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMURA Haruki HYOGO COLLEGE OF MEDICINE, DEPARTMENT OF MEDICINE, PROFESSOR, 医学部, 教授 (60111043)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1999: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1998: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | IL-18 / GRAFT-VERSUS-HOST DISEASE / 骨髄移植 |
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| Research Abstract |
Interleukin-18 (IL-18) augments IFN-γproduction in the presence of IL-12. IFN-γ and IL-12 are the cytokines that have been implicated in the pathogenesis of acute graft-versus-host disease (aGVHD) after allogeneic bone marrow transplantation (BMT). To elucidate the association of serum IL-18 and aGVHD, we serially measured serum levels of IL-18 in the patients with hematological malignancy after allogeneic. BMT. Circulating IL-18 was within the normal range in patients with acute and chronic leukemias in remission before BMT, and it did not change by preconditioning with intensive chemotherapy and/or total body irradiation. Patients with aGVHD had high levels of IL-18 that strongly correlated with the severity of aGVHD. Coincidental elevation of IFN-γ was observed during aGVHD but the elevation of IFN-γ was also observed during infection. Serum IL-12 levels did not correlate with serum IL-18 levels during aGVHD. These findings suggest that IL-18 may take part in the pathogenesis of aGVHD and that measurement of serum IL-18 levels can be useful indicator of aGVHD.
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Report
(3 results)
Research Products
(6 results)
