| Project/Area Number |
10670974
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | HYOGO COLLEGE OF MEDICINE |
|---|
Principal Investigator |
FUJIMORI Yoshihiro HYOGO COLLEGE OF MEDICINE, DEPARTMENT OF MEDICINE, ASSISTANT PROFESSOR, 医学部, 助手 (20229058)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OKAMURA Haruki HYOGO COLLEGE OF MEDICINE, DEPARTMENT OF MEDICINE, PROFESSOR, 医学部, 教授 (60111043)
|
|---|
| Project Period (FY) |
1998 – 1999
|
| Project Status |
Completed (Fiscal Year 1999)
|
| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1999: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1998: ¥1,600,000 (Direct Cost: ¥1,600,000)
|
|---|
| Keywords | IL-18 / GRAFT-VERSUS-HOST DISEASE / 骨髄移植 |
|---|
| Research Abstract |
Interleukin-18 (IL-18) augments IFN-γproduction in the presence of IL-12. IFN-γ and IL-12 are the cytokines that have been implicated in the pathogenesis of acute graft-versus-host disease (aGVHD) after allogeneic bone marrow transplantation (BMT). To elucidate the association of serum IL-18 and aGVHD, we serially measured serum levels of IL-18 in the patients with hematological malignancy after allogeneic. BMT. Circulating IL-18 was within the normal range in patients with acute and chronic leukemias in remission before BMT, and it did not change by preconditioning with intensive chemotherapy and/or total body irradiation. Patients with aGVHD had high levels of IL-18 that strongly correlated with the severity of aGVHD. Coincidental elevation of IFN-γ was observed during aGVHD but the elevation of IFN-γ was also observed during infection. Serum IL-12 levels did not correlate with serum IL-18 levels during aGVHD. These findings suggest that IL-18 may take part in the pathogenesis of aGVHD and that measurement of serum IL-18 levels can be useful indicator of aGVHD.
|
