| Project/Area Number |
10671039
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Endocrinology
|
|---|
| Research Institution | KYUSHU UNIVERSITY |
|---|
Principal Investigator |
YANASE Toshihiko Kyushu University, Graduate School of Medical Sciences, Associate Professor, 大学院・医学研究院, 助教授 (30239818)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAWATA Hajime Kyushu University, Graduate School of Medical Sciences, Associate Professor, 大学院・医学研究院, 教授 (10038820)
TAKAYANAGI Ryoichi Kyushu University, Graduate School of Medical Sciences, Associate Professor, 大学院・医学研究院, 教授 (30154917)
|
|---|
| Project Period (FY) |
1998 – 2000
|
| Project Status |
Completed (Fiscal Year 2000)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1998: ¥2,000,000 (Direct Cost: ¥2,000,000)
|
|---|
| Keywords | FTZ-F1β / Ad4BP / FTZ-F_1β / mLRH-1 / FTZ-F1 |
|---|
| Research Abstract |
FTZ-F1β had been implicated to be a counterpart of Ad4BP and mainly expressed in liver and pancreas. We elucidated the structure of the human FTZ-F1β gene. We determined the exonic sequences including the exon/intron baundaries and the sequences at the 5'-flanking region. The gene is at least 50 Kb long and is split into 8 exons including a non-coding exon 1. The overall structural organization of human FTZ-F1β gene was very similar to that of human Ad4BP/SF-1 gene, suggesting that both genes are derived from common ancestor gene. In addition, a preliminary study of transcriptional regulation of human FTZ-F1β gene in Hep G2 cells using a series of deletion analysies of the 5'-flanking region of human FTZ-F1β gene revealed a upstream region of -1743 to -1040 bp from the transcriptional statsite to be essential for the basal transcription of the human FTZ-F1β gene in Hep G2 cells.
|
