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Rapid loss of rat liver allograft immunogenicity

Research Project

Project/Area Number 10671123
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionNagasaki University School of Medicine

Principal Investigator

AZUMA Takashi  Nagasaki University School of Medicine, Surgery II, Lecturer, 医学部・附属病院, 講師 (60260733)

Co-Investigator(Kenkyū-buntansha) KANEMATSU Takashi  Nagasaki University School of Medicine, Surgery II, Professor, 医学部, 教授 (40128004)
FUJIOKA Hikaru  Nagasaki University School of Medicine, Surgery II, Lecturer, 医学部, 講師 (00264226)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1999: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1998: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsLIVER TRANSPLANTATION / NATURAL TOLERANCE / IMMUNOGENICITY / ANTIGEN PRESENTINGS CELL / トレランス / 遊走細胞 / ドナー抗原提示細胞 / リンパ球混合培養反応 / ラット
Research Abstract

In orthotopic liver transplantation form Lewis (LEW) into Wistar Furth (WF) rats, a transient rejection response is usually followed by spontaneous tolerance of the graft. In this study, we investigated the alloimmunostimulatory ability of the graft and recipient spleen after liver transplantation, and studied the kinetic response of the recipient were investigated in in vivo system. Alloimmunostimulatory ability of the liver graft disappeared by day 3 after transplantation. Alloimmunostimulatory capacity of recipient spleen was maximum 12 hours after grafting and rapidly disappeared thereafter. Challenge with normal LEW lymphocytes into recipient WF rats at 14, 28, 56 days after liver transplantation induced a progressive increase in rejection response. Our results suggested that rapid loss of graft immunogenicity and transient hyporesponsiveness to the donor antigen occur after grafting in our model.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Takao Yamamoto: "Differences in cellular mechanisms between heart and skin graft rejection by in vitro and in vivo analysis"Transplantation Proceedings. 30. 3854 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Weili Gu: "rapid Loss of Graft immunogenicity and transient hyporesponsiveness to the donor antigen after rat liver transplanation"The Acta medica Nagasakiensia. 44. 31-38 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takao Yamamoto: "Anti-CD4 induced rat heart tolerance: no pressure of primed T cells and regulatory mechanisms for cytotoxic T cells"Transplant Immunology. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takao Yamamoto, Junzo Yamaguchi, Weili Gu, Tatsuhiro Ishii, Toshiaki Hashimoto, Kazuyuki Usui, Takashi Azuma, Hikaru Fujioka, Junichiro Furui, Takashi Kanematsu: "Differences in cellular mechanisms between heart and skin graft rejection by in vitro and in vivo analysis"Transplantation Proceedings. 30. 3854 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Weili Gu, Junzo Yamaguchi, Toshiaki Hashimoto, Takao Yamamoto, Eiichi Nakayama, Takashi Kanematsu: "Rapid Loss of Graft Immunogenicity and transient hyporesponsiveness to the donor antigen after rat liver transplantation"The Acta Medica Nagasakiensia. 44, No3-4. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takao Yamamoto, Junzo Yamaguchi, Eiichi Nakayma, Takashi Kanematsu: "Anti-CD4 induced rat heart tolerance: no presence of primed T cells and regulatory mechanisms for cytotoxic T cells"Transplant Immunology. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Gu.W.: "Rapid loss of graft immunoglenicity and translent hypo-responsiveness to the clonor antigen after rat liver transplantation"Acta Med.Nagasaki. 44. 31-38 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamamoto T.: "Differences In cellular mechanism between heart and skin graft rejection - in vitro and in vivo analyses"Transplant.Proc. 30. 3854 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ishii T.: "Presence of CD4 Suppressor T Cells in Rat Liver Transplantation"Transplant Proc.. 30. 12 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamaguchi J.: "Difference in Cellular Mechanisms in Early and Late Immunological Responses After Liver Transplantation in Rats"Transplant Proc.. 28. 1782-1783 (1996)

    • Related Report
      1999 Annual Research Report
  • [Publications] Gu W.: "Loss of Antigenicity One Month after Liver Transplantation and Change of Serum Antibody Titer to Donor Antigens"Transplant Proc.. 28. 1084-1085 (1996)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamaguchi J.: "Long-Term Survival of Orthotopic LEWIS Liver Grafts in WISTAR FURTH Rats: Elimination or Inactivation of Effectors CTL and Altered Antigenicity as Possible Reasons for Tolerance"Transplanation. 57. 412-418 (1994)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamamoto T.: "Differences in cellular mechanism between heart and skin graft rejection-By in vitro and in vivo analyses." Transplant.Proc. 30. 3854 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ishii T.: "Presence of CD4 Suppressor T Cells in Rat Liver Transplantation." Transplant Proc.30. 12 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yamaguchi J.: "Difference in Cellular Mechanisms in Early and Late Immunological Responses After Liver Transplantation in Rats." Transplant.Proc. 28. 1782-1783 (1996)

    • Related Report
      1998 Annual Research Report
  • [Publications] Gu W.: "Loss of Antigenicity One Month after Liver Transplantation and Change of Serum Antibody Titer to Donor Antigens." Transplant Proc.28. 1084-1085 (1996)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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