| Project/Area Number |
10671135
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Teikyo University |
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Principal Investigator |
OKINAGA Kota Teikyo University School of Medicine Second Department of Surgery, Professor, 医学部, 教授 (00101098)
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| Co-Investigator(Kenkyū-buntansha) |
IINUMA Hisae Teikyo University School of Medicine Second Department of Surgery, Assistant, 医学部, 助手 (30147102)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2000: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1999: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1998: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Immunotherapy / Gastric cancer / Th1, Th2 / OK-432 / OK432 |
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| Research Abstract |
In this study, we assessed the usefulness of Th1/Th2 balance of peripheral blood lymphocytes (PBLs) for therapeutic monitoring of cancer immunotherapy using OK-432. A Total of 56 curative gastric cancer patients (OK-432 administration group : 38 patients ; non-administration group : 18 patients) were used as subjects, and 3 KE of OK-432 was administered intradermally once every 2 weeks for OK-432 administration group. The production of IFN- γ and IL-2 of PBLs in the OK-432-administered group were significantly higher than that of OK-432-non administered group, while the production of IL-4 was not significantly different between them. The patients who had been administered OK-432 were divided into two groups (high-response and low-response) according to the NK activity at three months after surgery. In patients administered OK-432, the balance of Th1/Th2 was changed to Th1-dominant status. OK-432 high response patients showed a significant increase in the ratio of Th1/Th2, as compared to low response patients, and Th1-dominant immunological status was confirmed.
These results suggest that the Th1/Th2 balance of PBLs is a useful indicator for monitoring of immunotherapy using OK-432 in patients with gastric cancer.
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