• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Mechanism of multiple organ failure caused by interaction of nitric oxide and oxidant stress

Research Project

Project/Area Number 10671142
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionKINKI UNIVERSITY

Principal Investigator

YONEKURA Takeo  Kinki University School of Medicine, Assistant Professor, 医学部, 講師 (00258021)

Co-Investigator(Kenkyū-buntansha) IMANO Motohiro  Kinki University School of Medicine, Assistant Professor, 医学部, 講師 (00278681)
KUBOTA Akio  Kinki University School of Medicine, Assistant Professor, 医学部, 講師 (10161671)
OOYANAGI Harumasa  Kinki University School of Medicine, Chief Professor, 医学部, 教授 (00030958)
HOKI Masanori  Kinki University School of Medicine, Assistant Professor, 医学部, 講師 (40278685)
HIROOKA Shinji  Kinki University School of Medicine, Assistant, 医学部, 助手 (10268394)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1998: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywordsnitric oxide / oxidant stress / ischemia reperfusion injury / glutathione / sepsis / hyperendotoxemia / drug delivery system / オキシダンストレス / 虚血再灌流障害 / poly(ADP-riboss)polymerase / benzamide / ATP / 酸素ラジカル / 虚血再灌流 / 臓器障害 / oxidant stress / 組織血流障害 / 循環障害 / グルタチオン
Research Abstract

Research 1 : Interaction of nitric oxide (NO) and free radical is suspected the cause of multiple organ failure in ischemia reperfusion injury. In this research, we evaluated effect of nitric oxide on oxidant stress to estimate mechanism of cellular injury in ischemia reperfusion using partial hepatic ischemia-reperfusion model. Rats were subjected to ischemia and reperfusion in the lateral lobe of the liver. After continuous administration of NG-nitro-L-arginine methyl ester (L-NAME), L-arginine (L-Arg) or saline, we evaluated tissue blood flow and concentrations of oxidized and reduced glutathione in the I/R-lobe and the non-I/R-lobe in each group. Inhibition of NO production deteriorated tissue blood flow, hepatic injury and oxidant stress in both the I/R-lobe and the non-I/R-lobe. Administration of L-Arg had only transient increase of tissue blood flow in the I/R-lobe, moreover deteriorated hepatic injury and oxidant stress.
Research 2 : Sepsis often causes multiple organ failure. To reveal the mechanism of septic organ failure, we developed a novel reproducible septic animal model applying drug delivery system (DDS). Rats implanted with DDS contained with lipopolysaccharide maintained high blood levels of endotoxin for 72 hours, and also exhibited septic condition.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] 米倉竹夫、窪田昭男: "新生児壊死性腸炎の病態-腸管阻血性病変とnitric oxide"医学のあゆみ. 12. 863-864 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yonekura T,Kubota A 他: "Intermittent obstruction of the inferior vena cava by congenital anteromedial diaphragmatic hernia : An extremely rare case of Budd-Chiari syndrome in an infant"Surgery. 124. 109-111 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 米倉竹夫: "アルギニン:生体におけるアルギニン-NO合成系の基質としてのアルギニンの役割について"JJPEN. 21. 469-478 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 米倉竹夫: "Nesidioblastosis"医学のあゆみ. 193. 1003-1007 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yonekura T,Hirooka S 他: "Surgical intervention for emphysematous pulmonary regions in a postoperative infant with congenital diaphragmatic hernia"J Pediatric Surg. 35. 1820-1821 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yonekura T,Kubota A 他: "Inhibition of nitric oxide production deteriorates intestinal ischemia reperfusion injury due to increased oxidant stress"Shock. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 米倉武夫: "系統小児外科学 第7章 人工臓器 付)Nitric oxide第1版"永井書店(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeo Yonekura, Akio Kubota: "Neonatal ischemic enterocolitis- intestinal ischemic lesion and nitric oxide"Igakunoayumi. 12. 863-864 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yonekura T, Kubota A, Hoki M, Asano S, Nakayama T, Kato M, Oyanagi M: "Intermittent obstruction of the inferior vena cava by congenital anteromedial diaphragmatic hernia : An extremely rare case of Budd-Chiari syndrome in an infant"Surgery. 124. 109-111 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeo Yonekura: "Arginine : Role of arginine for substrate of arginine-nitric oxide pathway"JJPEN. 21. 469-478 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeo Yonekura: "Nesidioblastosis"Igakunoayumi. 193. 1003-1007 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yonekura T, Hirooka S, Kubota A, Hoki M, Kosumi T, Yamauchi K, Oyanagi H: "Surgical intervention for emphysematous pulmonary regions in a postoperative infant with congenital diaphragmatic hernia"J Pediatric Surg. 35. 1820-1821 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yonekura T, Kubota A, Hoki M, Hirooka S, Kosumi T, Kato M, Oyanagi M: "Inhibition of nitric oxide production deteriorates intestinal ischemia reperfusion injury due to increased oxidant stress"Shock. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yonekura T,Kubota A,: "Inhibition of nitric production deteriorates intestinal ischemia reperfusion injyury due to increased"Shock. (印刷中).

    • Related Report
      1999 Annual Research Report
  • [Publications] 米倉竹夫: "アルギニン生体におけるLaginine nitric oxide(NO)系の基質としてのLaginineの役割について"JJPEN. 21. 469-478 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 米倉竹夫、窪田昭男: "新生児壊死性腸炎の病態-腸管虚血性病変とnitric oxide"医学のあゆみ. 186. 863 (1998)

    • Related Report
      1999 Annual Research Report

URL: 

Published: 1998-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi