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Expression of cancer-specific nuclear matrix protein in gastro-intestinal cancer

Research Project

Project/Area Number 10671163
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

ICHIKAWA Wataru  Digestive surgery, Tokyo Medical and Dental University Assistant, 大学院・医歯学総合研究科, 助手 (70282738)

Co-Investigator(Kenkyū-buntansha) OSANAI Takayuki  Digestive surgery, Tokyo Medical and Dental University Assistant, 医学部・附属病院, 助手 (50301164)
NIHEI Zenro  Digestive surgery, Tokyo Medical and Dental University Associate, 大学院・医歯学総合研究科, 助教授 (00189341)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2000: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1999: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1998: ¥2,500,000 (Direct Cost: ¥2,500,000)
Keywordscancer-specific antigen / nuclear matrix protein / 5-FU / gastro-intestinal cancer / モノクローナル抗体 / 癌特異的
Research Abstract

The aim of this study is to investigate the expression of cancer-specific nuclear matrix protein (NMP) in gastro-intestinal cancer. We evaluated the cancer-specific NMP (molecular weight ; 68kDa, electric point ; pH7.32) in human gastric cancer by two-dimensional gel electrophoresis, described by Fey et al.. This NMP expressed in various human cancer cell lines, including gastric and colorectal cancer. However, this protein in not specific for apoptosis. The establishment of anti-human cancer-specific NMP anti-body (Ab) was successfully performed by the conventional method using with hybridoma. The expression of this NMP was observed immunohistochemically in human materials. NMP expression was correlated with both tumor shrinkage and survival in patients treated with 5-FU based chemotherapy for metastatic tumors. This study indicates the clinical usefulness to determine the expression of cancer-specific NMP in gastro-intestinal cancer for predicting the biological behaviors.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] W.Ichikawa,H.Uetake,H.Yamada, et al: "Expression of dihydoropyrimidine dehedrogenase in primary lesion predicts the anti-tumor effect in 5-FU based chemotharpy for GI tract cancer"Proc Am Soc Clin Oncol. 19. 285a (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 市川度,植竹宏之,桐原正人 ほか: "抗癌剤標的酵素および代謝関連酵素発現からみた大腸癌化学療法の個性化"日本大腸肛門病会誌. 53巻・10号. 1023-1028 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] W.Ichikawa,H.Uetake,H.Yamada, et al: "Expression of dihydoropyrimidine dehedrogenase in primary lesion predicts the anti-tumor effect in 5-FU based chemotharpy for GI tract cancer"Proc Am Soc Clin Oncol. 19. 285a (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 市川度,植竹宏之,桐原正人 ほか: "抗癌剤標的酵素および代謝関連酵素発現からみた大腸癌化学療法の個性化"日本大腸肛門病会誌. 53巻・10号. 1023-1028 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hiroyuki Uetake, Wataru Ichikawa et al: "Relationship between intratumor dihydropyrimldime dehydrogenase Activity and gene expression in humory colorectal cancer"Clinical Cancer Research. 5. 2836-2839 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 市川 度 他: "胃癌に特異的な核マトリックス蛋白の発現" 日本外科学会雑誌. (発表予定).

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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