| Project/Area Number |
10671165
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Niigata University |
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Principal Investigator |
YAGI Minoru Niigata University Medical Hospital, Lecturer, 医学部・附属病院, 講師 (10251802)
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| Co-Investigator(Kenkyū-buntansha) |
IINUMA Yasushi Niigata University Hospital, Assistant, 医学部・附属病院, 助手 (00283010)
UCHIYAMA Masanori Niigata University faculty of Medicine, Associate Professor, 医学部, 助教授 (40151906)
IWAFUCHI Makoto Niigata University faculty of Medicine, Professor, 医学部, 教授 (00018326)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1999: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1998: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | Small intestinal transplant / Rejection / Preservation of organs / Short bowel syndrome / Small intestinal motility |
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| Research Abstract |
To evaluate availability of a transplanted small intestine, we measured changes of muscular activity of the translated intestine by using bipolar electrodes and force transducers, and pH range in the intestinal cavity, for postoperative period. Moreover, to judge suitability of methods of intestinal preservation, including in cold storage at 4 ℃ and a high pressure oxygen box, changes of activity and pH were examined by similar means. Basic electric rhythm (BER) was occurred in the transplanted intestine for 2-3 days, but action potentials (AP) did not take place regularly, and migrating myoelectric contraction (MMC) did not happen. Intestinal pH was fell toward acidity on condition of vascular obstacle, and ascended with tissue necrosis. In the preserved intestine, BER occurred initially, but disappeared within 6 hours. BER reappeared after returning intestinal temperature. PH of the reserved intestine held around 5 during cold state, but arose according to normal temperature.
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