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Molecular Analysis of the Mechanisms of Proliferation of the Small intestine

Research Project

Project/Area Number 10671168
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKanazawa University

Principal Investigator

SHIMAZU Koichi  Kanazawa University, University Hospital, Assistant Professor, 医学部・附属病院, 講師 (30196513)

Co-Investigator(Kenkyū-buntansha) TANI Takashi  Kanazawa University, University Hospital, Instructor, 医学部・附属病院, 助手 (50257466)
Project Period (FY) 1998 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2001: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2000: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordssmall intestinal mucosa / regeneration and proliferation / c-fos / c-jun / aging / massive small bowel resection / ischemia / reperfusion injury / EMSA法 / NF-κB / AP-1 / PCNA標識率 / 蛋白合成比速度 / 増殖能 / アポトーシス / 絶食
Research Abstract

The immediate early genes are induced rapidly and transiently in most tissues after a wide variety of injury. These genes are regulate the expression of cellular response after injury. We investigated the expression of c-fos and c-jun genes in small intestinal mucosal epithelium of rats after various injuries. In the study to determine the effect of aging on growth of the small intestinal epithelium following fasting and refeeding, the expression of c-fos and c-jun mRNA significantly increased after refeeding in young rats than in adult rats, as well as the proliferative activity. In the study to investigate the mechanism of regeneration and degeneration of small intestinal mucosa following ischemia/reperfusion, the expression of c-fos and c-jun mRNA and the proliferative activity increased markedly after reperfusion. Interestingly, apoptotic cells were observed in villi and were consistent with the expression of c-Fos and c-Jun proteins. In the study to investigate the compensatory mucosal proliferation of the residual small intestine after massive small bowel resection, the massive small bowel group showed an increase in the expression of c-fos and c-jun mRNA after the operative procedure. From these results, overexpression of c-fos and c-jun play an important role in regenaration and proliferation of small intestinal mucosal epithelium in the studies that we performed. Now, we have been researching the signal transduction system using ischemia/reperfusion model in rats.

Report

(5 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] 伊藤 博: "小腸阻血・再潅流と前初期遺伝子c-fos, c-junの過剰発現に関する実験的研究"金沢大学十全医学会雑誌. 106・6. 644-653 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 根塚秀昭: "小腸粘膜増殖の加齢に伴う変化と前初期遺伝子c-fos, c-junの発現に関する実験的研究"金沢大学十全医学会雑誌. 108・2. 157-165 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hiroshi Ito: "Activation of immediate early gene, c-fos and c-jun in the rat small intestine after ischemia/reperfusion"Transplantation. 69・4. 598-604 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hiroshi, Ito: "Overexpression of immediate early gene, c-fos and c-jun in the rat small intestine after ischemia/reperfusion"J Juzen Med Soc. 106-6. 644-653 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hideaki Nezuka: "Age-related changes in the expression of the immediate early gene, c-fos and c-jun in the regenerating small intestine of rats"J Juzen Med Soc. 108-2. 157-165 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hiroshi Ito: "Activation of immediate early gene, c-fos and c-jun in the rat small intestine after ischemia/reperfusion"Transplantation. 69-4. 598-604 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 伊藤 博: "小腸阻血・再潅流と前初期遺伝子c-fos, c-junの過剰発現に関する実験的研究"金沢大学十全医学会雑誌. 106・6. 644-653 (1997)

    • Related Report
      2001 Annual Research Report
  • [Publications] 根塚秀昭: "小腸粘膜増殖の加齢に伴う変化と前初期遺伝子c-fos, c-junの発現に関する実験的研究"金沢大学十全医学会雑誌. 108・2. 157-165 (1999)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hiroshi Ito: "Activation of immediate early gene, c-fos and c-jun in the rat small intestine after ischemia/reperfusion"Transplantation. 69・4. 598-604 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] 伊藤博: "小腸阻血・再潅流と前初期遺伝子c-fos,c-junの過剰発現に関する実験的研究"金沢大学十全医学会雑誌. 106・6. 644-653 (1997)

    • Related Report
      2000 Annual Research Report
  • [Publications] 根塚秀昭: "小腸粘膜増殖の加齢に伴う変化と前初期遺伝子c-fos,c-junの発現に関する実験的研究"金沢大学十全医学会雑誌. 108・2. 157-165 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hiroshi Ito: "Activation of immediate early gene, c-fos and c-jun in the rat small intestine after ischemia/reperfusion"Transplantation. 69・4. 598-604 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 根塚秀昭: "小腸粘膜増殖の加齢に伴う変化と前初期遺伝子c-fos,c-junの発言に関する実験的研究"金沢大学十全医学会雑誌. 108巻2号. 157-165 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 伊藤博: "Activation of immediate early gene, c-fos, and c-jun in the rat small intestine after ischemia/reperfusion"Transplantation. vol69,No4. 598-604 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 伊藤 博: "小腸阻血・再灌流と前初期遺伝子c-fos,c-junの過剰発現に関する実験的研究" 十全医会誌. 106. 644-653 (1997)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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