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Basic studies on the mechanisms of improved glucose

Research Project

Project/Area Number 10671189
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionShimane Medical University

Principal Investigator

SUMI Shoichiro  Shimane Med. Univ. 1st Dept. of Surg. Lecturer, 医学部, 講師 (80252906)

Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1999: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1998: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordspancreatectomy / glucose tolerance / gastrin / proton pump inhibitor / CCK-B receptor antagonist / pancreas regeneration / stomach / rat
Research Abstract

In order to investigate whether proton pump inhibitor (PPI) ameliorates glucose tolerance after pancreatectomy through hypergastrinemia, 90% pancreatectomized rats (male Wistar) were treated as follows ; Group 1 : vehicle alone, Group 2 : PPI (lansoprazol, 30 mg/kg body weigh), Group 3 : gastrin/CCK-B receptor inhibitor (GRI, AR-041R, 30 mg/kg BW), Group 4 : PPI and GRI. The drugs were daily administered into the stomach. Normal rats were also examined. Fourteen days after pancreatectomy (Px), plasma gastrin levels were significantly increased by PPI and tended to be additionally increased by GRI. Wet weight of the organ/body weight ratio (ww/BW) of the pabcreas was increased in Px rats in comparison to the remnant equivalent of the normal rats. However, significant difference was not seen among the Px groups. The ww/bw of the stomach was significantly increased in Px groups and partly reduced by GRI. Either changes in body weight or plasma glucose concentration at fed state were not different among Px groups. Intragastric glucose challenge (2g/kg BW) did not show the difference in plasma glucose or insulin concentrations among Px groups.
This study did not reproduce the effect of PPI on glucose tolerance after Px, however the changes in gastric weight was reproductively observed as was shown in our previous study. ィイD1*ィエD1Cahnges in glucose tolerance after Px seemed to be delicately influenced by a little differences in the rate of Px and/or other unknown factors. On the other hand, the role of gastrin on Px-induced increase in gastric weight was partly evaluated by the effect of GRI, which fully antagonized PPI-induced increase but did not abolish the Px-induced increase. Therefore, some factor(s) other than circulation gastrin mainly mediates Px-induced increase in gastric weight.
ィイD1*ィエD1 : Xu G, Sumi S, et al. Role of endogenous hypergastrinemia in regenerating endocrine pancreas after partial pancreatectomy. Dig Dis Sci 41 : 2433-2469 1996

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 角 昭一郎、田村 勝洋: "消化管と膵との相関 -外科的立場より-"Frontiers in Gstroenterology. 3. 175-181 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 角 昭一郎,他: "膵切除と膵再生"現代医療. 31. 3097-3102 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sumi, S., Tamura, K.: "Frontiers of pancreas regeneration"Journal of Hepato-Biliary-Pancreatic Surgery. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sumi S, Tamura K.: "Interrelationship between digestive tract and pancreas-from surgical aspect- (in Japanese)"Frontiers in Gastroenterology. 3. 175-181 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sumi S, Yano S, Nio Y, Tamura K.: "Pancreatectomy and Pancreas regeneration (in Japanese)"New Horizon for Medicine. 31. 3097-3102 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sumi S, Tamura K.: "Frontiers of pancreas regeneration"Journal of Hepato-Biliary-Pancreatic Surgery. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary

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Published: 1998-04-01   Modified: 2016-04-21  

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