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Generation of pro-inflammatory and anti-inflammatory cytokines in the gut

Research Project

Project/Area Number 10671191
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionHiroshima University

Principal Investigator

TAKESUE Yoshio  Hiroshima University, Faculty of Medicine, Assistant professor, 医学部, 講師 (70197292)

Co-Investigator(Kenkyū-buntansha) IMAMURA Yuji  Hiroshima University, Medical Hospital, Research Associate, 医学部・附属病院, 助手 (70274082)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥2,700,000 (Direct Cost: ¥2,700,000)
KeywordsSIRS / CARS / zymosan / peritonitis / gut / IL-6 / TNF-α / IL-10 / バクテリアルトランスロケーション / Zymosan / サイトカイン
Research Abstract

In major systemic inflammation such as severe peritonitis, various pro-inflammatory cytokines, such as TNF- α, IL-1 β and IL-6, play important roles in the development of multiple organ dysfunction syndrome (MODS). The purpose of this study was to investigate the outflow of pro-inflammatory and anti-inflammatory cytokines from the efferent mesenteric lymphatic vessels under peritonitis. Mesenteric lymph samples were collected from adult male rats at 2, 4-, 6, 8 and 10 hours after an intraperitoneal injection of zymosan at a dosage of 0.1 mg/g (non-lethal dose) or 0.5 mg/g (lethal dose). Blood samples were obtained at IC hours after zymosan administration. The amounts of drained TNF-α and IL-6 in the lymph peaked at 2-4 hr and 4-8 hr after zymosan administration, respectively. The amounts of drained IL-10 in the lymph gradually increased until 10 hours. The amounts of drained TNF-α and IL-10 in the mesenteric lymph were significantly correlated with the dosage of zymosan.
In conclusion, under intraperitoneal inflammation, pro-inflammatory cytokines (TNF-α and IL-6) increased in the mesenteric lymph and were drained into circulation. IL-10, one of the anti-inflammatory cytokines, also increased in the mesenteric lymph after several hours' delay and its increase was remarkable in severe inflammations. These findings suggested that the gut might be one of the pro-inflammatory and anti-inflammatory cytokine-generating organs under peritonitis. The lymph-drained amounts of each cytokine under peritonitis are considered to differ with the time or severity of inflammation, which may cause different conditions in patients due to the imbalance of pro-inflammatory and anti-inflammatory cytokines.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (90 results)

All Other

All Publications (90 results)

  • [Publications] Sakashita Y: "Generation of pro-inflammatory and anti-inflammatory cytokines in the gut in zymosan-induced peritonits"Hiroshinla J.Med.Sci.. 49(1). 43-48 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 竹末 芳生: "術後感染発症阻止抗菌薬の選択条件と使用法"JAPAN CLIPPING TODAY. 33-35 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 竹末 芳生: "術後感染発症阻止抗菌薬の選択条件と使用法"Info Medica. 1-3 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 竹末 芳生: "緑膿菌における治療薬の選択理由とその実績"日本外科感染症研究. 11. 219-222 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 竹末 芳生: "外科領域における抗菌薬適正使用"THE JOURNAL OF INFECTION CONTROL. 8. 42-45 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 竹末 芳生: "消化器手術におけるflomoxefの腸内細菌叢への影響"日本化学療法学会雑誌. 47. 75-78 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takesue Y: "Changes in intcstinal flora after administration of penipenem/betamipron or sullbactam/cefoperazonc for treatment of postoperative infections in gastrectomy patients"Japan Society of Chemotherapy. 5. 52-57 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takesue Y: "The Effectiveness of Perineal Rectosigmoridectomy for the Treatment ofRactal Prolapse in Elderly and High-Risk Patients"Surgery Today. 29. 290-293 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Santo T: "Analysis of mec regulator genes in clinical mcthicillin-resistant staphylococcus aureus isolates according to the production of coagulasc,types of enterotoxin,and toxic shock syndrome toxin-I"Hiroshima j.Med.Sci.. 48(1). 49-56 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 竹末 芳生: "手術後感染予防のための抗菌薬投与と術後創部感染"Medicina. 36. 137-139 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 横山 隆: "bacterial translocationは敗血症の原因として重要である"集中治療. 11. 1138-1142 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 横山 隆: "バンコマイシン耐性院内感染菌の出現-耐性のメカニズム-"Surgery Frontier. 6. 49-53 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 横山 隆: "急性腹症の鑑別診断"カレントテラピー. 17. 621-626 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 横山 隆: "感染防止とゾーニング"臨床透析. 92. 876-885 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takesue Y: "Prediction for development of postoperative infections in the operation of esophageal cancer compared with cancer"Hiroshima J.Med.Sci.. 47(3). 109-113 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 竹末 芳生: "High risk患者への予防的抗菌薬投与法"外科. 60. 870-875 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 横山 隆: "外科的感染症-紛瘤,毛巣炎,蜂窩織炎-"外科治療. 79. 392-397 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 竹末 芳生: "術後高度耐性菌感染症"消化器外科NURSING. 3. 93-100 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 横山 隆: "多剤耐性菌感染症での抗菌薬選択法"集中治療. 10. 1177-1184 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 横山 隆: "加齢に伴う変化-免疫機能(感染防御能を中心に)"老年消化器病. 10. 111-117 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 横山 隆: "消化管不全"救急医学. 22. 1954-1958 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 大毛 宏喜: "急性上腸間膜静脈血栓症の2手術例"日本腹部救急医学会雑誌. 18. 323-326 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 大毛 宏喜: "広島大学第一外科における胆嚢癌41例の治療成績の検討"広島医学. 51. 925-928 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 横山 隆: "外科分子病態学"小川道雄、斎藤英昭編.医学書院,東京. 158-162 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 横山 隆: "臨床医のための救急疾患キーワード"小川道雄編 診断と治療社,東京. 47-51 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 横山 隆: "臨床侵襲学"小川道雄,斉藤英昭編.へるす出版 東京. 62-70 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 横山 隆: "消化器外科周術期感染症."炭山嘉伸編著.南山堂,東京. 227-234 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 横山 隆: "院内感染対策テキスト"日本感染症学会編,へるす出版,東京. 63-69 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 横山 隆: "耐性菌感染症の理論と実際"平松 啓一編 医薬ジャーナル社 大阪. 217-221 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 竹末芳生: "SIRS(全身性炎症反応症候群)"医歯薬出版株式会社.東京. 47-51 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] SAKASHITA Y. ET AL: "Generation of pro-inflammatory and anti-inflammatory cytokines in the gut in zymosan-induced peritonitis."Hiroshima J. Med., Sci.. 49(1). 43-48 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] TAKESUE Y: "Choice and clinical use of prophylactic antimicrobial agents."JAPAN CLIPPING TODAY. 33-35 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] TAKESUE Y: "Choice and clinical use of prophylactic antimicrobial agents."Info Medica. 1-3 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] TAKESUE Y. ET AL: "Clinical use of Antimicrobial Agents in Infections by Pseudomonas Aeruginosa."Surgical Infection Society of Japan. 11. 219-222 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] TAKESUE Y. ET AL: "Clinical use of antimicrobial agents in surgical department."THE JOURNAL OF INFECTION CONTROL. 8. 42-45 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] TAKESUE Y. ET AL: "Impact on intestinal flora after administration of flomoxef in gastroenterological surgery."Jpn. J. Chemother. 47. 75-79 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] TAKESUE ET AL: "Changes in intestinal flora after administration of penipenem/betamipron or sullbactam/cefoperazone for treatment .of postoperative infections in gastrectomy patients."Japan Society of Chemotherapy. 5. 52-57 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] TAKESUE Y. ET AL: "The Effectiveness of Perineal Rectosigmoridectomy for the Treatment of Rectal Prolapse in Elderly and High-Risk Patients."Surgery Today. 29. 290-293 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] SANTO T. ET AL: "Analysis of mec regulator genes in clinical methicillin-resistant staphylococcus aureus isolates according to the production of coagulase, types of enterotoxin, and toxic shock syndrome toxin-1."Hiroshima j. Med. Sci.. 48(2). 49-56 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] TAKESUE Y. ET AL: "Clinical use of antimicrobial agents for prevention of surgical -site infection."Medicina.. 36. 137-139 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YOKOYAMA T. ET AL: "Significance of bacterial translocation as the cause of sepsis."Intensive & Critical Care Medicine. 11. 1138-1142 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YOKOYAMA T. ET AL: "Emerging of vancomycin resistant hospital strains mechanism of vancomycin resistance expression."Surgery Frontier. 6. 49-53 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YOKOYAMA T. ET AL: "Differential diagnosis of acute abdomen."CURRENT THERAPY. 17(4). 621-626 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YOKOYAMA T. ET AL: "Prevention of nosocomial infection and zoning."The Japanese Journal of Clinical Dialysis. 15(7). 876-885 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] TAKESUE YOSHIO. ET AL: "Prodiction for development of postoperative infections in the operation of esophageal cancer compared with gastric cancer."Hiroshima J. Med. Sci.. 47(3). 109-113 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YOKOYAMA T. ET AL: "Administrations of prophylactic antibiotics for high risk patient."Surgery. 60. 870-875 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YOKOYAMA T. ET AL: "Surgical soft tissue infection- infected atheroma, perifolliculitis (furuncle, furunculosis, carbuncle), ccllulites."Surgical Therapy. 79(4). 392-397 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] TAKESUE Y. ET AL: "Postoperative infection highly-resistant organisms."GASTROENTELOGICAL SURGERY NURSING. 3(1). 93-100 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YOKOYAMA T. ET AL: "Choice of antimicrobial agents in the treatment of multiple drug resistant organisms."Intensive & Critical Care Medicine. 10(11). 1177-1184 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YOKOYAMA T. ET AL: "Age-related changes in immune function."RONEN SHOUKAKIBYOU. 10(2). 111-117 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YOKOYAMA T. ET AL: "Acute gastric mucosal lesion and bacterial translocation."The Japanese Journal of Acute Medicine. 22(13). 1954-1958 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] OHGE H. ET AL: "Two operated cases of acute superior mesenteric vein thrombosis."Journal of Abdominal Emergency Medicine. 18(2). 323-326 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] OHGE H. ET AL: "Survey of surgical treatment for gallbladder carcinoma at the first department of surgery Hiroshima University Hospital."J. Hiroshima Med. Ass.. 51(7). 925-928 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YOKOYAMA T.: "Bacterial adhesion and growth"OGAWA M. SAITOH H.. 158-162 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YOKOYAMA T.: "Bacterial translocation"OGAWA M.. 47-51 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YOKOYAMA T. ET AL: "Infection"OGAWA M. SAITOH H.. 62-70 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YOKOYAMA T.: "Anaerobic bacterium infectious disease"SUMIYAMA Y.. 227-234 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YOKOYAMA T. ET AL: "Water supply and drainage, Operation room, Biocleanness ward"The Japanese Association for infectious disease. 63-69 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] YOKOYAMA T. ET AL: "Postoperative infection by highly-resistant organisms"HIRAMATSU K.. 217-221 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] TAKESUE Y. ET AL: "New concept of bacterial translocation and its role in the pathogenesis of SIRS"ISHIYAKU-SHUPPAN. 47-51 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sakashita Y: "Generation of pro-inflammatory and anti-inflammatory cytokines in the gut in zymosan-induced peritonitis."Hiroshima J. Med. Sci.. 49(1). 43-48 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 竹末 芳生: "術後感染発症阻止抗菌薬の選択条件と使用法"JAPAN CLIPPING TODAY. 33-35 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 竹末 芳生: "術後感染発症阻止抗菌薬の選択条件と使用法"Info Medica. 1-3 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 竹末 芳生: "緑膿菌における治療薬の選択理由とその実際"日本外科感染症研究. 11. 219-222 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 竹末 芳生: "外科領域における抗菌薬適正使用"THE JOURNAL OF INFECTION CONTROL. 8. 42-45 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 竹末 芳生: "消化器手術における flomoxefの腸内細菌叢への影響"日本化学療法学会雑誌. 47. 75-78 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takesue T: "Changes in intestinal flora after administration of penipenem/betamipron or sullbactam/cefoperazone for treatment of postoperative infections in gastrectomy patients"Japan Society of Chemotherapy. 5. 52-57 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takesue T: "The Effectiveness of Perineal Rectosigmoridctomy for the Treatment of Rectal Prolapse in Elderly and High-Risk Patients"Surgery Today. 29. 290-293 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Santo T: "Analysis of mec regulator genes in clinical methiclin-resistant staphylococcus aureus isolates according to the production of coagulasc,types of enterotoxin,and toxic shock syndrome toxin-1"Hiroshima j. Med. Sei.. 48(2). 49-56 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 竹末 芳生: "手術後感染防止のための抗菌薬投与と術後創部感染"Medicina. 36. 137-139 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 横山 隆: "bacterial teanslocation は敗血症の原因として重要である"集中治療. 11. 1138-1142 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 横山 隆: "バンコマイシン耐性院内感染菌の出現-耐性のメカニズム"Surgery Frontier. 6. 49-53 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 横山 隆: "急性腹症の鑑別診断"カントテラピー. 17. 621-626 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 横山 隆: "感染防止とゾーニング"臨床透析. 92. 876-885 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takesue T: "Prediction for development of postoperative infections in the operation of esophageal cancer compared with gastric cancer."Hiroshima j. Med. Sei.. 47(3). 109-113 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 竹末 芳生: "High risk患者への予防的抗菌薬投与法"外科. 60. 870-875 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 横山 隆: "外科的感染症-粉瘤,毛巣炎,蜂窩織炎-"外科治療. 79. 392-397 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 竹末 芳生: "術後高度耐性菌感染症"消化器外科 NURSING. 3. 93-100 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 横山 隆: "多剤耐性菌感染症での抗菌薬選択法"集中治療. 10. 1177-1184 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 横山 隆: "加齢に伴う変化-免疫機能(感染防御能を中心に)"老年消化器病. 10. 111-117 (1998)

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      1999 Annual Research Report
  • [Publications] 横山 隆: "消化管不全"救急医学. 22. 1954-1958 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 大毛 宏喜: "急性上腸間膜静脈血栓症の2手術例"日本腹部救急医学会雑誌. 18. 323-326 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 大毛 宏喜: "広島大学第一外科における胆嚢癌41例の治療成績の検討"広島医学. 51. 925-928 (1998)

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      1999 Annual Research Report
  • [Publications] 横山 隆: "外科分子病態学"小川道雄・斉藤英昭編・医学書院,東京. 5 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 横山 隆: "臨床医のための救急疾患キーワード"小川道雄編 診断と治療社,東京. 5 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 横山 隆: "臨床浸襲学"小川道雄・斉藤英昭編・へるす出版,東京. 9 (1998)

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      1999 Annual Research Report
  • [Publications] 横山 隆: "消化器外科周術期感染症."炭山嘉伸編・南山堂,東京. 8 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 横山 隆: "院内感染対策テキスト"日本感染症学会編,へるす出版,東京. 7 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 横山 隆: "耐性菌感染症の理論と実際"平松 啓一編 医薬ジャーナル社 大阪. 5 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 竹末芳生: "SIRS(全身性炎症反応症候群)"医歯薬出版株式会社.東京. 5 (1998)

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      1999 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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