MECHANISM OF PERINEUTAL INVASION OF PANCREATIC CANCER-USING IMMUNOHISTOCHEMICAL TECHNIQUE NCAM PSA-
| Project/Area Number |
10671208
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | YOKOHAMA CITY UNIVERSITY, SCHOOL OF MEDICINE |
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Principal Investigator |
ICHIKAWA Yasushi AS-PROF. DEPT. OF SURGERY-II, YOKOHAMA CITY UNIV., 医学部, 助手 (00244434)
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| Co-Investigator(Kenkyū-buntansha) |
市川 靖史 横浜市立大学, 医学部, 助手 (70254208)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1998: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Pancreatic Cancer / NCAM / Polycyclic Acid / Neural Invasion / 神経周囲浸潤 / Neural Cell Adhesion Molecule |
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| Research Abstract |
Neurotoropism of pancreatic cancer is one of the hypotheses explaining neural invasion, which is one of the characteristics of pancreatic cancer. In these studies we Immunohistochemically examined neural cell adhesion molecule (NCAM), hemophilic adhesion molecules expressed on the nerve cells, as a factor of neurotropism in 15 pancreatic cancer operatively obtained, especially In neural Invasive lesions. We also Investigated the role of polycyclic acid (PSA), which is attached to NCAM and related to the malignant potential of cancers. NCAM was detected In 66.7% of pancreatic cancers, and all 9 cases with massive pleural invasion. In neural invasion, however, there were perineurium and endoneurium, which do not express NCAM, between cancer and the nerve cells. PSA was also detected pancreatic cancers expressing NCAM. Moreover, PSA expression was stronger In the perineural Invasive lesions than in the main tumor and was related to the cancer cell proliferation Investigated by Ki-67 staining. It is unlikely therefore, that NCAN plays an Important role in neurotropism. However, the NCAM expressed on the pancreatic cancer was attached to PSA, which itself plays an Important role In the malignant potential of this disease.
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Report
(3 results)
Research Products
(3 results)
