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Development of peptide vaccines for HLA-A24ィイD1+ィエD1 esophageal cancer patients.

Research Project

Project/Area Number 10671230
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKurume University

Principal Investigator

YAMANA Hideaki  Kurume Univ., Sch. Med., Dep. Surg., Associate Professor, 医学部, 助教授 (30140669)

Co-Investigator(Kenkyū-buntansha) NAKAO Masanobu  Kurume Univ., Sch. Med., Dep. Immunol., Lecturer, 医学部, 講師 (40258447)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1999: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1998: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsPeptides / Vaccine / Esophageal / Cytotoxic T lymphocyte / HLA-A24 / Specific immunotherapy / SART-1 peptide / SART-3 peptide / SAR-1ペプチド
Research Abstract

A main objective of this research project is to develop of peptide vaccines useful for HLA-A24ィイD1+ィエD1 patients with esophageal cancer. We have identified five tumor-rejection antigens (SART1-SART5) from cDNA esophageal cancer cells that were recognized by HLA-A24-restricted m derived from an esophageal cancer patient. SART-1, SART-2, and SART-3 tumor rejective antigens were newly identified molecules, while the remaining two were known molecules (Lck and PI9). SART-1, SART-2, SART-3, and PI9 tumor-rejection antigens were broadly expressed in the majority of esophageal cancers, while Lck was preferentially expressed in metastatic esophageal cancers. Peptide antigens recognized by the CTLs, and those capable of inducing HLA-class I restricted CTLs from peripheral blood mononuclear cells (PBMCs) of esophageal cancer patients were also identified in these tumor-rejection antigens. SART-1ィイD2690-698ィエD2 or SART-1ィイD2736-744ィエD2 peptide is currently used for phase I clinical studies as cancer vaccines in HLA-A24ィイD1+ィエD1 or -A26ィイD1+ィエD1 esophageal respectively, in our Kurume University Hospital. These basic and clinical research shall provide new insight for better understanding of molecular basis of T cell-mediated recognition of cancer cells. Further, these studies

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (35 results)

All Other

All Publications (35 results)

  • [Publications] Shichijo, S., Yamana H., et al.: "A Gene encoding antigenic peotides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes"J. Exp. Med.. 187. 277-288 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yang, D., Yamana H., et al.: "Identification of a gene coding for a protein possissing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients"Cancer Research. 59. 4056-4063 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kikuchi, M., Yamana H., et al.: "Identification of a SART-1-derived peptoide capable of inducing tne HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes"Int. J. Cancer. 81. 459-466 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakao, M., Yamana H., et al.: "Identification of a gene coding for a new squamous cell carcinoma antigen recognized by cytotoxic T lymphocytes"J. Immunol.. 164. 2565-2574 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Inoue, Y., Yamana H., et al.: "Induction of HLA-A26-restricted and tumor-specific cytotoxic T lymphocytes by a single peptide of the SART1 antigen in cancer patients with different A26 subtypes"J. Immunotherapy. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Niiya, F., Yamana H., et al.: "Expression of SART3 tumor-rejection antigen in gastric cancers"JJCR. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shichijo, S., Yamana H., et al.: "Gann Monograph on Cancer Research No. 48"Kikuchi, K., and Sato T.. (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Itoh, K., Yamana H, et al.: "Cell Therapy"Ikeda, Y., and Kawakami, Y., (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toh U, Ymana H, Fujit H, Ymaga H, Ozaki K, Shirouzu K, Itoh K: "Establishment of HLA class I-restricted and tumor specific CTLs in patients with esophageal cancer"Biotherapy. 12(1). 56-61 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fujii T, Yamana H, Fujita H, Sueyochi S, Nakashima A, Hayashi I, Nishi M, Kato S, Shirouzu K, Suematsu M: "Clinicopathologic study of multiple primary superficial carcinoma of the esophagus."Int. J. Oncol. 12. 421-425 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shichijo S, Nakao M, Imai Y, Takasu H, Kawamoto M, Niiya F, Yang D, Toh Y, Yamana H, Itoh K: "A gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes."J. Exp. Med.. 187(3)277288. 277-288 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoshida S, Yamana H, Tanaka T, Ishibashi N, Toh U, Ishii H, Shirouzu K: "Effect of combination therapy with a methionine-mitomycin C conjugate and a methionine-defecient diet on tumor growth"vivo. 12351-356 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoshida S, Matsui M, Shirouzu Y, Fujita H, Yamana H, Shirouzu K: "Effect of glutamine supplements and radiochemotherapy on systemic immune and gut barrier function in patients with advanced esophageal cancer."Ann Surg. 227(4). 485-491 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hikida S, Takeuchi M, Hata H, Yamana H, Fujita H, Shirouzu K, Matsuno K, Tanaka T, Kawaguchi C, Akiyoshi K, Tsuru T, Mizote H: "Free jejunal graft autotransplantation should be revascularized within 3 hours"Transplantation. 30(7). 3446-3448 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toh U, Yamana H, Sueyoshi S, Fujita H, Kubota H, Sasahara H, Shirouzu K, Itoh K: "Specific adoptive immunotherapy with autologous tumor cell-activated lymphocytes for esophageal cancer"Biotherapy. 14(1). 26-28 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fujita H, Kakegawa T, Sueyoshi S, Hikita S, Mine T, Tanaka Y, Ishikawa H, Shirouzu K, Mori K, Inoue Y, Yanaga Tanabe H, Kiyokawa K, Tai Y, Inutsuka H: "Total esophagectomy veersus proximal esophagectomy for esophageal cancer at the cervicothoracic junction."World J Surg. 23. 486-491 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kikuchi M, Nakao M, Inoue Y, Matsunaga K, Shichijo S, Yamana H, Itoh K: "Identification of a SART-1-dereived peptide capable of including HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes."Int J Cancer. 81. 486-466 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nojiri H, Manya H, Isono H, Yamana H, Nojima S: "induction of terminal differentiation and apoptosis in human colonic carcinoma dells by brefeldin A, a drug affecting ganglioside biosynthesis."FEBS Letters. 453. 140-144 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yang D, Nakao M, Shichijo S, Sasatomi T, Tanaka H, Matsumoto H, Mori K, Hayashi A, Yamana H, Shirouzu K, Itoh K: "Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients1."Cancer Res. 59. 4056-4063 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Inoue, Y., Nakao, M., Matsunaga, K,. Kikuchi, M., Gomi, S., Takamori, S., Yamana, H., and Itoh, K.: "Induction of HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes by a single peptide of the SART-1 antigen in cancer patients with different A26 subtypes."J. Immunotherapy. in press. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakao. M., Shichijo, S., Imaizumi, T., Inoue, Y., Matsunaga, K., Yamada, A., Kikuchi, M., Tsuda, N., Takamori, S., Yamana, H., Fujita, H., and Itoh, K.: "Identification of a gene coding for anew squamous cell carcinoma antigen recognized by cytotoxic T lymphocytes."J. Immunol.. 164. 2565-2574 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Niiya, F., Shichijo, S., Nishizaka, S., Matsunaga, K., Koufuji, K., Mori, M., Katai, H., Yamana, H., and Itoh, K.: "Expression of SRAT-3 tumor-rejection antigen in gastric cancers."JJCR. in press. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ssatomi, T., Yamana, H., Shichijo, S., Tanaka, S., Okamura, Y., Shirouzu, K., and Itoh, K.: "Expression of SART-1 tumor-rejection antigen in colorectal cancers"Colon and Rectum. in press. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mine, T., Harada, K., Matsumoto, T., Yamana, H., Itoh, K., and Yamada, A.: "Expression of CDw108 antigen during T cell development"Tissue Antigen. in press. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shichijo,S.,Yamana,H.,et al.: "A Gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes."J.Exp.Med.. 187. 277-288 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yang,D.,Yamana,H.,et al.: "Identification of a gene coding for a protein possissing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients."Cancer Research. 59. 4056-4063 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kikuchi,M.,Yamana,H.,et al.: "Identification of a SART-1-derived peptoide capable of inducing the HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes."Int.J.Cancer. 81. 459-466 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nakao,M.,Yamana,H.,et al.: "Identification of a gene coding for a new squamous cell carcinoma antigen recognized by cytotoxic T lymphocytes."J.Immunol.. (March 1 issue)(in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Inoue,Y.,Yamana,H.,et al.: "Induction of HLA-A26-restricted and tumor-specific cytotoxic T lymphocytes by a single peptide of the SART 1 antigen in cancer patients with different A26 subtypes."J.Immunotherapy. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Niiya,F.,Yamana,H.,et al.: "Expression of SART3 tumor-rejection antigen in gastric cancers."JJCR. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shichijo,S.,Yamana,H.,et al.: "Gann Monograph on Cancer Research No.48"Kikuchi,K.,and Sato,T.. (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Itoh,K.,Yamana,H.,et al.: "Cell Therapy"Ikeda,Y.,and Kawakami,Y., (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shichijo,S.,Yamana,H.,et al: "A Gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes." J.Exp.Med.187. 277-288 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kikuchi,M.,Yamana,H.,et al.: "Identification of a SART-1-derived peptoide capable of inducing the HLA-A24- restricted and tumor-specific cytotoxic T lymphocytes." Int.J.Cancer. (In press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shichijo,S.,Yamana,H.,et al.: "Gann Monograph on Cancer Research No.48" Japan Scientific Societies Press,Tokyo (in press), (1999)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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